eF-site ID 5uci-D PDB Code 5uci Chain D click to enlarge Title Hsp90b N-terminal domain with inhibitors Classification Chaperone/Inhibitor Compound Heat shock protein HSP 90-beta Source Homo sapiens (Human) (HS90B_HUMAN) Sequence D:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI GYPITLYL Description Functional site 1) chain D residue 43 type sequence L description binding site for residue 874 D 301 source : AC8 2) chain D residue 46 type sequence N description binding site for residue 874 D 301 source : AC8 3) chain D residue 47 type sequence A description binding site for residue 874 D 301 source : AC8 4) chain D residue 50 type sequence A description binding site for residue 874 D 301 source : AC8 5) chain D residue 53 type sequence K description binding site for residue 874 D 301 source : AC8 6) chain D residue 88 type sequence D description binding site for residue 874 D 301 source : AC8 7) chain D residue 93 type sequence M description binding site for residue 874 D 301 source : AC8 8) chain D residue 102 type sequence L description binding site for residue 874 D 301 source : AC8 9) chain D residue 133 type sequence F description binding site for residue 874 D 301 source : AC8 10) chain D residue 179 type sequence T description binding site for residue 874 D 301 source : AC8 11) chain D residue 181 type sequence V description binding site for residue 874 D 301 source : AC8 12) chain D residue 17 type sequence F description binding site for residue GOL D 302 source : AC9 13) chain D residue 18 type sequence Q description binding site for residue GOL D 302 source : AC9 14) chain D residue 19 type sequence A description binding site for residue GOL D 302 source : AC9 15) chain D residue 101 type sequence N description binding site for residue DMS D 303 source : AD1 16) chain D residue 130 type sequence G description binding site for residue DMS D 303 source : AD1 17) chain D residue 134 type sequence Y description binding site for residue DMS D 303 source : AD1 18) chain D residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 22) chain D residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3

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