eF-site ID 5uci-C PDB Code 5uci Chain C click to enlarge Title Hsp90b N-terminal domain with inhibitors Classification Chaperone/Inhibitor Compound Heat shock protein HSP 90-beta Source Homo sapiens (Human) (HS90B_HUMAN) Sequence C:  HMPEEVHHGEEVETFAFQAEIAQLMSLIINTFYSNKEIFL RELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQ ERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKE VVKKHSQFIGYPITLYL Description Functional site 1) chain C residue 17 type sequence F description binding site for residue GOL B 303 source : AC5 2) chain C residue 18 type sequence Q description binding site for residue GOL B 303 source : AC5 3) chain C residue 19 type sequence A description binding site for residue GOL B 303 source : AC5 4) chain C residue 43 type sequence L description binding site for residue 874 C 301 source : AC6 5) chain C residue 46 type sequence N description binding site for residue 874 C 301 source : AC6 6) chain C residue 47 type sequence A description binding site for residue 874 C 301 source : AC6 7) chain C residue 50 type sequence A description binding site for residue 874 C 301 source : AC6 8) chain C residue 53 type sequence K description binding site for residue 874 C 301 source : AC6 9) chain C residue 86 type sequence L description binding site for residue 874 C 301 source : AC6 10) chain C residue 88 type sequence D description binding site for residue 874 C 301 source : AC6 11) chain C residue 91 type sequence I description binding site for residue 874 C 301 source : AC6 12) chain C residue 93 type sequence M description binding site for residue 874 C 301 source : AC6 13) chain C residue 133 type sequence F description binding site for residue 874 C 301 source : AC6 14) chain C residue 179 type sequence T description binding site for residue 874 C 301 source : AC6 15) chain C residue 181 type sequence V description binding site for residue 874 C 301 source : AC6 16) chain C residue 101 type sequence N description binding site for residue DMS C 302 source : AC7 17) chain C residue 130 type sequence G description binding site for residue DMS C 302 source : AC7 18) chain C residue 134 type sequence Y description binding site for residue DMS C 302 source : AC7 19) chain C residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain C residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 23) chain C residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3

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