eF-site ID 5uci-ABCD
PDB Code 5uci
Chain A, B, C, D

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Title Hsp90b N-terminal domain with inhibitors
Classification Chaperone/Inhibitor
Compound Heat shock protein HSP 90-beta
Source Homo sapiens (Human) (HS90B_HUMAN)
Sequence A:  GHMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEI
FLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN
PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ
AGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWE
SSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRV
KEVVKKHSQFIGYPITLYL
B:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD
ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT
GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF
GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA
DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI
GYPITLYL
C:  HMPEEVHHGEEVETFAFQAEIAQLMSLIINTFYSNKEIFL
RELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQ
ERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS
AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKE
VVKKHSQFIGYPITLYL
D:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD
ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT
GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF
GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA
DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI
GYPITLYL
Description


Functional site

1) chain A
residue 43
type
sequence L
description binding site for residue 874 A 301
source : AC1

2) chain A
residue 46
type
sequence N
description binding site for residue 874 A 301
source : AC1

3) chain A
residue 47
type
sequence A
description binding site for residue 874 A 301
source : AC1

4) chain A
residue 49
type
sequence D
description binding site for residue 874 A 301
source : AC1

5) chain A
residue 50
type
sequence A
description binding site for residue 874 A 301
source : AC1

6) chain A
residue 86
type
sequence L
description binding site for residue 874 A 301
source : AC1

7) chain A
residue 88
type
sequence D
description binding site for residue 874 A 301
source : AC1

8) chain A
residue 92
type
sequence G
description binding site for residue 874 A 301
source : AC1

9) chain A
residue 93
type
sequence M
description binding site for residue 874 A 301
source : AC1

10) chain A
residue 133
type
sequence F
description binding site for residue 874 A 301
source : AC1

11) chain A
residue 179
type
sequence T
description binding site for residue 874 A 301
source : AC1

12) chain A
residue 181
type
sequence V
description binding site for residue 874 A 301
source : AC1

13) chain A
residue 101
type
sequence N
description binding site for residue DMS A 302
source : AC2

14) chain A
residue 130
type
sequence G
description binding site for residue DMS A 302
source : AC2

15) chain B
residue 43
type
sequence L
description binding site for residue 874 B 301
source : AC3

16) chain B
residue 46
type
sequence N
description binding site for residue 874 B 301
source : AC3

17) chain B
residue 47
type
sequence A
description binding site for residue 874 B 301
source : AC3

18) chain B
residue 49
type
sequence D
description binding site for residue 874 B 301
source : AC3

19) chain B
residue 50
type
sequence A
description binding site for residue 874 B 301
source : AC3

20) chain B
residue 88
type
sequence D
description binding site for residue 874 B 301
source : AC3

21) chain B
residue 91
type
sequence I
description binding site for residue 874 B 301
source : AC3

22) chain B
residue 93
type
sequence M
description binding site for residue 874 B 301
source : AC3

23) chain B
residue 133
type
sequence F
description binding site for residue 874 B 301
source : AC3

24) chain B
residue 179
type
sequence T
description binding site for residue 874 B 301
source : AC3

25) chain B
residue 181
type
sequence V
description binding site for residue 874 B 301
source : AC3

26) chain B
residue 101
type
sequence N
description binding site for residue DMS B 302
source : AC4

27) chain B
residue 106
type
sequence A
description binding site for residue DMS B 302
source : AC4

28) chain B
residue 130
type
sequence G
description binding site for residue DMS B 302
source : AC4

29) chain B
residue 16
type
sequence A
description binding site for residue GOL B 303
source : AC5

30) chain B
residue 17
type
sequence F
description binding site for residue GOL B 303
source : AC5

31) chain B
residue 19
type
sequence A
description binding site for residue GOL B 303
source : AC5

32) chain C
residue 17
type
sequence F
description binding site for residue GOL B 303
source : AC5

33) chain C
residue 18
type
sequence Q
description binding site for residue GOL B 303
source : AC5

34) chain C
residue 19
type
sequence A
description binding site for residue GOL B 303
source : AC5

35) chain C
residue 43
type
sequence L
description binding site for residue 874 C 301
source : AC6

36) chain C
residue 46
type
sequence N
description binding site for residue 874 C 301
source : AC6

37) chain C
residue 47
type
sequence A
description binding site for residue 874 C 301
source : AC6

38) chain C
residue 50
type
sequence A
description binding site for residue 874 C 301
source : AC6

39) chain C
residue 53
type
sequence K
description binding site for residue 874 C 301
source : AC6

40) chain C
residue 86
type
sequence L
description binding site for residue 874 C 301
source : AC6

41) chain C
residue 88
type
sequence D
description binding site for residue 874 C 301
source : AC6

42) chain C
residue 91
type
sequence I
description binding site for residue 874 C 301
source : AC6

43) chain C
residue 93
type
sequence M
description binding site for residue 874 C 301
source : AC6

44) chain C
residue 133
type
sequence F
description binding site for residue 874 C 301
source : AC6

45) chain C
residue 179
type
sequence T
description binding site for residue 874 C 301
source : AC6

46) chain C
residue 181
type
sequence V
description binding site for residue 874 C 301
source : AC6

47) chain C
residue 101
type
sequence N
description binding site for residue DMS C 302
source : AC7

48) chain C
residue 130
type
sequence G
description binding site for residue DMS C 302
source : AC7

49) chain C
residue 134
type
sequence Y
description binding site for residue DMS C 302
source : AC7

50) chain D
residue 43
type
sequence L
description binding site for residue 874 D 301
source : AC8

51) chain D
residue 46
type
sequence N
description binding site for residue 874 D 301
source : AC8

52) chain D
residue 47
type
sequence A
description binding site for residue 874 D 301
source : AC8

53) chain D
residue 50
type
sequence A
description binding site for residue 874 D 301
source : AC8

54) chain D
residue 53
type
sequence K
description binding site for residue 874 D 301
source : AC8

55) chain D
residue 88
type
sequence D
description binding site for residue 874 D 301
source : AC8

56) chain D
residue 93
type
sequence M
description binding site for residue 874 D 301
source : AC8

57) chain D
residue 102
type
sequence L
description binding site for residue 874 D 301
source : AC8

58) chain D
residue 133
type
sequence F
description binding site for residue 874 D 301
source : AC8

59) chain D
residue 179
type
sequence T
description binding site for residue 874 D 301
source : AC8

60) chain D
residue 181
type
sequence V
description binding site for residue 874 D 301
source : AC8

61) chain A
residue 16
type
sequence A
description binding site for residue GOL D 302
source : AC9

62) chain A
residue 17
type
sequence F
description binding site for residue GOL D 302
source : AC9

63) chain A
residue 19
type
sequence A
description binding site for residue GOL D 302
source : AC9

64) chain D
residue 17
type
sequence F
description binding site for residue GOL D 302
source : AC9

65) chain D
residue 18
type
sequence Q
description binding site for residue GOL D 302
source : AC9

66) chain D
residue 19
type
sequence A
description binding site for residue GOL D 302
source : AC9

67) chain D
residue 101
type
sequence N
description binding site for residue DMS D 303
source : AD1

68) chain D
residue 130
type
sequence G
description binding site for residue DMS D 303
source : AD1

69) chain D
residue 134
type
sequence Y
description binding site for residue DMS D 303
source : AD1

70) chain A
residue 33-42
type prosite
sequence YSNKEIFLRE
description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE
source prosite : PS00298

71) chain A
residue 46
type BINDING
sequence N
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

72) chain D
residue 46
type BINDING
sequence N
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

73) chain D
residue 107
type BINDING
sequence K
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

74) chain D
residue 133
type BINDING
sequence F
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

75) chain A
residue 107
type BINDING
sequence K
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

76) chain A
residue 133
type BINDING
sequence F
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

77) chain B
residue 46
type BINDING
sequence N
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

78) chain B
residue 107
type BINDING
sequence K
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

79) chain B
residue 133
type BINDING
sequence F
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

80) chain C
residue 46
type BINDING
sequence N
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

81) chain C
residue 107
type BINDING
sequence K
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

82) chain C
residue 133
type BINDING
sequence F
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

83) chain A
residue 88
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

84) chain B
residue 88
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

85) chain C
residue 88
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

86) chain D
residue 88
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

87) chain A
residue 126
type SITE
sequence I
description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402
source Swiss-Prot : SWS_FT_FI3

88) chain B
residue 126
type SITE
sequence I
description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402
source Swiss-Prot : SWS_FT_FI3

89) chain C
residue 126
type SITE
sequence I
description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402
source Swiss-Prot : SWS_FT_FI3

90) chain D
residue 126
type SITE
sequence I
description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402
source Swiss-Prot : SWS_FT_FI3


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