eF-site ID 5uci-ABCD PDB Code 5uci Chain A, B, C, D click to enlarge Title Hsp90b N-terminal domain with inhibitors Classification Chaperone/Inhibitor Compound Heat shock protein HSP 90-beta Source Homo sapiens (Human) (HS90B_HUMAN) Sequence A:  GHMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEI FLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPN PQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ AGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWE SSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRV KEVVKKHSQFIGYPITLYL B:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI GYPITLYL C:  HMPEEVHHGEEVETFAFQAEIAQLMSLIINTFYSNKEIFL RELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQ ERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKE VVKKHSQFIGYPITLYL D:  EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD ALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDT GIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQF GVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRA DHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFI GYPITLYL Description Functional site 1) chain A residue 43 type sequence L description binding site for residue 874 A 301 source : AC1 2) chain A residue 46 type sequence N description binding site for residue 874 A 301 source : AC1 3) chain A residue 47 type sequence A description binding site for residue 874 A 301 source : AC1 4) chain A residue 49 type sequence D description binding site for residue 874 A 301 source : AC1 5) chain A residue 50 type sequence A description binding site for residue 874 A 301 source : AC1 6) chain A residue 86 type sequence L description binding site for residue 874 A 301 source : AC1 7) chain A residue 88 type sequence D description binding site for residue 874 A 301 source : AC1 8) chain A residue 92 type sequence G description binding site for residue 874 A 301 source : AC1 9) chain A residue 93 type sequence M description binding site for residue 874 A 301 source : AC1 10) chain A residue 133 type sequence F description binding site for residue 874 A 301 source : AC1 11) chain A residue 179 type sequence T description binding site for residue 874 A 301 source : AC1 12) chain A residue 181 type sequence V description binding site for residue 874 A 301 source : AC1 13) chain A residue 101 type sequence N description binding site for residue DMS A 302 source : AC2 14) chain A residue 130 type sequence G description binding site for residue DMS A 302 source : AC2 15) chain B residue 43 type sequence L description binding site for residue 874 B 301 source : AC3 16) chain B residue 46 type sequence N description binding site for residue 874 B 301 source : AC3 17) chain B residue 47 type sequence A description binding site for residue 874 B 301 source : AC3 18) chain B residue 49 type sequence D description binding site for residue 874 B 301 source : AC3 19) chain B residue 50 type sequence A description binding site for residue 874 B 301 source : AC3 20) chain B residue 88 type sequence D description binding site for residue 874 B 301 source : AC3 21) chain B residue 91 type sequence I description binding site for residue 874 B 301 source : AC3 22) chain B residue 93 type sequence M description binding site for residue 874 B 301 source : AC3 23) chain B residue 133 type sequence F description binding site for residue 874 B 301 source : AC3 24) chain B residue 179 type sequence T description binding site for residue 874 B 301 source : AC3 25) chain B residue 181 type sequence V description binding site for residue 874 B 301 source : AC3 26) chain B residue 101 type sequence N description binding site for residue DMS B 302 source : AC4 27) chain B residue 106 type sequence A description binding site for residue DMS B 302 source : AC4 28) chain B residue 130 type sequence G description binding site for residue DMS B 302 source : AC4 29) chain B residue 16 type sequence A description binding site for residue GOL B 303 source : AC5 30) chain B residue 17 type sequence F description binding site for residue GOL B 303 source : AC5 31) chain B residue 19 type sequence A description binding site for residue GOL B 303 source : AC5 32) chain C residue 17 type sequence F description binding site for residue GOL B 303 source : AC5 33) chain C residue 18 type sequence Q description binding site for residue GOL B 303 source : AC5 34) chain C residue 19 type sequence A description binding site for residue GOL B 303 source : AC5 35) chain C residue 43 type sequence L description binding site for residue 874 C 301 source : AC6 36) chain C residue 46 type sequence N description binding site for residue 874 C 301 source : AC6 37) chain C residue 47 type sequence A description binding site for residue 874 C 301 source : AC6 38) chain C residue 50 type sequence A description binding site for residue 874 C 301 source : AC6 39) chain C residue 53 type sequence K description binding site for residue 874 C 301 source : AC6 40) chain C residue 86 type sequence L description binding site for residue 874 C 301 source : AC6 41) chain C residue 88 type sequence D description binding site for residue 874 C 301 source : AC6 42) chain C residue 91 type sequence I description binding site for residue 874 C 301 source : AC6 43) chain C residue 93 type sequence M description binding site for residue 874 C 301 source : AC6 44) chain C residue 133 type sequence F description binding site for residue 874 C 301 source : AC6 45) chain C residue 179 type sequence T description binding site for residue 874 C 301 source : AC6 46) chain C residue 181 type sequence V description binding site for residue 874 C 301 source : AC6 47) chain C residue 101 type sequence N description binding site for residue DMS C 302 source : AC7 48) chain C residue 130 type sequence G description binding site for residue DMS C 302 source : AC7 49) chain C residue 134 type sequence Y description binding site for residue DMS C 302 source : AC7 50) chain D residue 43 type sequence L description binding site for residue 874 D 301 source : AC8 51) chain D residue 46 type sequence N description binding site for residue 874 D 301 source : AC8 52) chain D residue 47 type sequence A description binding site for residue 874 D 301 source : AC8 53) chain D residue 50 type sequence A description binding site for residue 874 D 301 source : AC8 54) chain D residue 53 type sequence K description binding site for residue 874 D 301 source : AC8 55) chain D residue 88 type sequence D description binding site for residue 874 D 301 source : AC8 56) chain D residue 93 type sequence M description binding site for residue 874 D 301 source : AC8 57) chain D residue 102 type sequence L description binding site for residue 874 D 301 source : AC8 58) chain D residue 133 type sequence F description binding site for residue 874 D 301 source : AC8 59) chain D residue 179 type sequence T description binding site for residue 874 D 301 source : AC8 60) chain D residue 181 type sequence V description binding site for residue 874 D 301 source : AC8 61) chain A residue 16 type sequence A description binding site for residue GOL D 302 source : AC9 62) chain A residue 17 type sequence F description binding site for residue GOL D 302 source : AC9 63) chain A residue 19 type sequence A description binding site for residue GOL D 302 source : AC9 64) chain D residue 17 type sequence F description binding site for residue GOL D 302 source : AC9 65) chain D residue 18 type sequence Q description binding site for residue GOL D 302 source : AC9 66) chain D residue 19 type sequence A description binding site for residue GOL D 302 source : AC9 67) chain D residue 101 type sequence N description binding site for residue DMS D 303 source : AD1 68) chain D residue 130 type sequence G description binding site for residue DMS D 303 source : AD1 69) chain D residue 134 type sequence Y description binding site for residue DMS D 303 source : AD1 70) chain A residue 33-42 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298 71) chain A residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 72) chain D residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 73) chain D residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 74) chain D residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 75) chain A residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 76) chain A residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 77) chain B residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 78) chain B residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 79) chain B residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 80) chain C residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 81) chain C residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 82) chain C residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 83) chain A residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 84) chain B residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 85) chain C residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 86) chain D residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 87) chain A residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 88) chain B residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 89) chain C residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 90) chain D residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3

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