eF-site ID 5uc4-C PDB Code 5uc4 Chain C click to enlarge Title Hsp90b N-terminal domain with inhibitors Classification CHAPERONE/INHIBITOR Compound Heat shock protein HSP 90-beta Source Homo sapiens (Human) (HS90B_HUMAN) Sequence C:  HMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIF LRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNP QERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQA GADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWES SAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVK EVVKKHSQFIGYPITLYL Description Functional site 1) chain C residue 43 type sequence L description binding site for residue 83S C 301 source : AC6 2) chain C residue 46 type sequence N description binding site for residue 83S C 301 source : AC6 3) chain C residue 50 type sequence A description binding site for residue 83S C 301 source : AC6 4) chain C residue 88 type sequence D description binding site for residue 83S C 301 source : AC6 5) chain C residue 91 type sequence I description binding site for residue 83S C 301 source : AC6 6) chain C residue 92 type sequence G description binding site for residue 83S C 301 source : AC6 7) chain C residue 133 type sequence F description binding site for residue 83S C 301 source : AC6 8) chain C residue 179 type sequence T description binding site for residue 83S C 301 source : AC6 9) chain C residue 181 type sequence V description binding site for residue 83S C 301 source : AC6 10) chain C residue 16 type sequence A description binding site for residue GOL C 302 source : AC7 11) chain C residue 17 type sequence F description binding site for residue GOL C 302 source : AC7 12) chain C residue 18 type sequence Q description binding site for residue GOL C 302 source : AC7 13) chain C residue 19 type sequence A description binding site for residue GOL C 302 source : AC7 14) chain C residue 101 type sequence N description binding site for residue DMS C 303 source : AC8 15) chain C residue 106 type sequence A description binding site for residue DMS C 303 source : AC8 16) chain C residue 130 type sequence G description binding site for residue DMS C 303 source : AC8 17) chain C residue 131 type sequence V description binding site for residue DMS C 303 source : AC8 18) chain C residue 134 type sequence Y description binding site for residue DMS C 303 source : AC8 19) chain C residue 126 type SITE sequence I description Cleaved under oxidative stress => ECO:0000269|PubMed:22848402 source Swiss-Prot : SWS_FT_FI3 20) chain C residue 133 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 46 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain C residue 107 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain C residue 88 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2

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