eF-site ID 5u2n-B PDB Code 5u2n Chain B click to enlarge Title Crystal structure of human NAMPT with A-1326133 Classification Transferase/Transferase Inhibitor Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence B:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain B residue 18 type sequence Y description binding site for residue SO4 A 501 source : AC1 2) chain B residue 197 type sequence G description binding site for residue SO4 A 503 source : AC3 3) chain B residue 383 type sequence G description binding site for residue SO4 A 503 source : AC3 4) chain B residue 384 type sequence G description binding site for residue SO4 A 503 source : AC3 5) chain B residue 18 type sequence Y description binding site for residue 7TA A 504 source : AC4 6) chain B residue 40 type sequence R description binding site for residue SO4 B 501 source : AC5 7) chain B residue 392 type sequence R description binding site for residue SO4 B 501 source : AC5 8) chain B residue 398 type sequence S description binding site for residue SO4 B 501 source : AC5 9) chain B residue 400 type sequence K description binding site for residue SO4 B 501 source : AC5 10) chain B residue 392 type sequence R description binding site for residue SO4 B 502 source : AC6 11) chain B residue 393 type sequence D description binding site for residue SO4 B 502 source : AC6 12) chain B residue 196 type sequence R description binding site for residue SO4 B 503 source : AC7 13) chain B residue 246 type sequence E description binding site for residue SO4 B 503 source : AC7 14) chain B residue 247 type sequence H description binding site for residue SO4 B 503 source : AC7 15) chain B residue 311 type sequence R description binding site for residue SO4 B 503 source : AC7 16) chain B residue 313 type sequence D description binding site for residue SO4 B 503 source : AC7 17) chain B residue 188 type sequence Y description binding site for residue 7TA B 504 source : AC8 18) chain B residue 191 type sequence H description binding site for residue 7TA B 504 source : AC8 19) chain B residue 193 type sequence F description binding site for residue 7TA B 504 source : AC8 20) chain B residue 196 type sequence R description binding site for residue 7TA B 504 source : AC8 21) chain B residue 219 type sequence D description binding site for residue 7TA B 504 source : AC8 22) chain B residue 244 type sequence A description binding site for residue 7TA B 504 source : AC8 23) chain B residue 275 type sequence S description binding site for residue 7TA B 504 source : AC8 24) chain B residue 307 type sequence P description binding site for residue 7TA B 504 source : AC8 25) chain B residue 311 type sequence R description binding site for residue 7TA B 504 source : AC8 26) chain B residue 349 type sequence R description binding site for residue 7TA B 504 source : AC8 27) chain B residue 351 type sequence I description binding site for residue 7TA B 504 source : AC8 28) chain B residue 379 type sequence A description binding site for residue 7TA B 504 source : AC8 29) chain B residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 30) chain B residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 31) chain B residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 32) chain B residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 33) chain B residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 34) chain B residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 35) chain B residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 36) chain B residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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