eF-site ID 5u2n-AB PDB Code 5u2n Chain A, B click to enlarge Title Crystal structure of human NAMPT with A-1326133 Classification Transferase/Transferase Inhibitor Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence A:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNIE B:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNI Description Functional site 1) chain A residue 196 type sequence R description binding site for residue SO4 A 501 source : AC1 2) chain A residue 246 type sequence E description binding site for residue SO4 A 501 source : AC1 3) chain A residue 247 type sequence H description binding site for residue SO4 A 501 source : AC1 4) chain A residue 311 type sequence R description binding site for residue SO4 A 501 source : AC1 5) chain A residue 313 type sequence D description binding site for residue SO4 A 501 source : AC1 6) chain B residue 18 type sequence Y description binding site for residue SO4 A 501 source : AC1 7) chain A residue 40 type sequence R description binding site for residue SO4 A 502 source : AC2 8) chain A residue 392 type sequence R description binding site for residue SO4 A 502 source : AC2 9) chain A residue 398 type sequence S description binding site for residue SO4 A 502 source : AC2 10) chain A residue 400 type sequence K description binding site for residue SO4 A 502 source : AC2 11) chain A residue 392 type sequence R description binding site for residue SO4 A 503 source : AC3 12) chain B residue 197 type sequence G description binding site for residue SO4 A 503 source : AC3 13) chain B residue 383 type sequence G description binding site for residue SO4 A 503 source : AC3 14) chain B residue 384 type sequence G description binding site for residue SO4 A 503 source : AC3 15) chain A residue 188 type sequence Y description binding site for residue 7TA A 504 source : AC4 16) chain A residue 191 type sequence H description binding site for residue 7TA A 504 source : AC4 17) chain A residue 193 type sequence F description binding site for residue 7TA A 504 source : AC4 18) chain A residue 196 type sequence R description binding site for residue 7TA A 504 source : AC4 19) chain A residue 219 type sequence D description binding site for residue 7TA A 504 source : AC4 20) chain A residue 242 type sequence V description binding site for residue 7TA A 504 source : AC4 21) chain A residue 244 type sequence A description binding site for residue 7TA A 504 source : AC4 22) chain A residue 275 type sequence S description binding site for residue 7TA A 504 source : AC4 23) chain A residue 309 type sequence I description binding site for residue 7TA A 504 source : AC4 24) chain A residue 311 type sequence R description binding site for residue 7TA A 504 source : AC4 25) chain A residue 349 type sequence R description binding site for residue 7TA A 504 source : AC4 26) chain A residue 351 type sequence I description binding site for residue 7TA A 504 source : AC4 27) chain A residue 379 type sequence A description binding site for residue 7TA A 504 source : AC4 28) chain B residue 18 type sequence Y description binding site for residue 7TA A 504 source : AC4 29) chain B residue 40 type sequence R description binding site for residue SO4 B 501 source : AC5 30) chain B residue 392 type sequence R description binding site for residue SO4 B 501 source : AC5 31) chain B residue 398 type sequence S description binding site for residue SO4 B 501 source : AC5 32) chain B residue 400 type sequence K description binding site for residue SO4 B 501 source : AC5 33) chain A residue 197 type sequence G description binding site for residue SO4 B 502 source : AC6 34) chain A residue 383 type sequence G description binding site for residue SO4 B 502 source : AC6 35) chain A residue 384 type sequence G description binding site for residue SO4 B 502 source : AC6 36) chain B residue 392 type sequence R description binding site for residue SO4 B 502 source : AC6 37) chain B residue 393 type sequence D description binding site for residue SO4 B 502 source : AC6 38) chain A residue 18 type sequence Y description binding site for residue SO4 B 503 source : AC7 39) chain B residue 196 type sequence R description binding site for residue SO4 B 503 source : AC7 40) chain B residue 246 type sequence E description binding site for residue SO4 B 503 source : AC7 41) chain B residue 247 type sequence H description binding site for residue SO4 B 503 source : AC7 42) chain B residue 311 type sequence R description binding site for residue SO4 B 503 source : AC7 43) chain B residue 313 type sequence D description binding site for residue SO4 B 503 source : AC7 44) chain A residue 18 type sequence Y description binding site for residue 7TA B 504 source : AC8 45) chain B residue 188 type sequence Y description binding site for residue 7TA B 504 source : AC8 46) chain B residue 191 type sequence H description binding site for residue 7TA B 504 source : AC8 47) chain B residue 193 type sequence F description binding site for residue 7TA B 504 source : AC8 48) chain B residue 196 type sequence R description binding site for residue 7TA B 504 source : AC8 49) chain B residue 219 type sequence D description binding site for residue 7TA B 504 source : AC8 50) chain B residue 244 type sequence A description binding site for residue 7TA B 504 source : AC8 51) chain B residue 275 type sequence S description binding site for residue 7TA B 504 source : AC8 52) chain B residue 307 type sequence P description binding site for residue 7TA B 504 source : AC8 53) chain B residue 311 type sequence R description binding site for residue 7TA B 504 source : AC8 54) chain B residue 349 type sequence R description binding site for residue 7TA B 504 source : AC8 55) chain B residue 351 type sequence I description binding site for residue 7TA B 504 source : AC8 56) chain B residue 379 type sequence A description binding site for residue 7TA B 504 source : AC8 57) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 58) chain B residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 59) chain B residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 60) chain B residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 61) chain B residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 62) chain B residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 63) chain A residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 64) chain A residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 65) chain A residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 66) chain A residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 67) chain A residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 68) chain A residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 69) chain B residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 70) chain B residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 71) chain A residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI2 72) chain B residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI2 73) chain A residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 74) chain B residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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