eF-site ID 5u2n-A PDB Code 5u2n Chain A click to enlarge Title Crystal structure of human NAMPT with A-1326133 Classification Transferase/Transferase Inhibitor Compound Nicotinamide phosphoribosyltransferase Source Homo sapiens (Human) (NAMPT_HUMAN) Sequence A:  FNILLATDSYKVTHYKQYPPNTSKVYSYFECREYEETVFY GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKG WNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPE CYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDT VAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKD AFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKG YKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAF GSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHT VFKNGKVTKSYSFDEIRKNAQLNIE Description Functional site 1) chain A residue 196 type sequence R description binding site for residue SO4 A 501 source : AC1 2) chain A residue 246 type sequence E description binding site for residue SO4 A 501 source : AC1 3) chain A residue 247 type sequence H description binding site for residue SO4 A 501 source : AC1 4) chain A residue 311 type sequence R description binding site for residue SO4 A 501 source : AC1 5) chain A residue 313 type sequence D description binding site for residue SO4 A 501 source : AC1 6) chain A residue 40 type sequence R description binding site for residue SO4 A 502 source : AC2 7) chain A residue 392 type sequence R description binding site for residue SO4 A 502 source : AC2 8) chain A residue 398 type sequence S description binding site for residue SO4 A 502 source : AC2 9) chain A residue 400 type sequence K description binding site for residue SO4 A 502 source : AC2 10) chain A residue 392 type sequence R description binding site for residue SO4 A 503 source : AC3 11) chain A residue 188 type sequence Y description binding site for residue 7TA A 504 source : AC4 12) chain A residue 191 type sequence H description binding site for residue 7TA A 504 source : AC4 13) chain A residue 193 type sequence F description binding site for residue 7TA A 504 source : AC4 14) chain A residue 196 type sequence R description binding site for residue 7TA A 504 source : AC4 15) chain A residue 219 type sequence D description binding site for residue 7TA A 504 source : AC4 16) chain A residue 242 type sequence V description binding site for residue 7TA A 504 source : AC4 17) chain A residue 244 type sequence A description binding site for residue 7TA A 504 source : AC4 18) chain A residue 275 type sequence S description binding site for residue 7TA A 504 source : AC4 19) chain A residue 309 type sequence I description binding site for residue 7TA A 504 source : AC4 20) chain A residue 311 type sequence R description binding site for residue 7TA A 504 source : AC4 21) chain A residue 349 type sequence R description binding site for residue 7TA A 504 source : AC4 22) chain A residue 351 type sequence I description binding site for residue 7TA A 504 source : AC4 23) chain A residue 379 type sequence A description binding site for residue 7TA A 504 source : AC4 24) chain A residue 197 type sequence G description binding site for residue SO4 B 502 source : AC6 25) chain A residue 383 type sequence G description binding site for residue SO4 B 502 source : AC6 26) chain A residue 384 type sequence G description binding site for residue SO4 B 502 source : AC6 27) chain A residue 18 type sequence Y description binding site for residue SO4 B 503 source : AC7 28) chain A residue 18 type sequence Y description binding site for residue 7TA B 504 source : AC8 29) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 30) chain A residue 219 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 31) chain A residue 247 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 32) chain A residue 311 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 33) chain A residue 353 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 34) chain A residue 384 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI1 35) chain A residue 392 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 36) chain A residue 188 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 472 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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