eF-site ID 5tbr_18-A
PDB Code 5tbr
Model 18
Chain A

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Title The Solution Structure of the Magnesium-bound Conantokin-R1B Mutant
Classification TOXIN
Compound Conantokin-R1-B
Source (5TBR)
Sequence A:  GEXXLAXKAAXFARXLANYX
Description (1)  Conantokin-R1-B


Functional site

1) chain A
residue 3
type BINDING
sequence X
description via 4-carboxyglutamate => ECO:0000269|PubMed:26048991
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 7
type BINDING
sequence X
description via 4-carboxyglutamate => ECO:0000269|PubMed:26048991
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 11
type BINDING
sequence X
description via 4-carboxyglutamate => ECO:0000269|PubMed:26048991
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 15
type BINDING
sequence X
description via 4-carboxyglutamate => ECO:0000269|PubMed:26048991
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 8
type SITE
sequence K
description Important for selectivity => ECO:0000305|PubMed:22594498, ECO:0000305|PubMed:26048991, ECO:0000305|PubMed:27981829
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 3
type MOD_RES
sequence X
description 4-carboxyglutamate => ECO:0000250|UniProtKB:P07231, ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI4

7) chain A
residue 4
type MOD_RES
sequence X
description 4-carboxyglutamate => ECO:0000250|UniProtKB:P07231, ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI4

8) chain A
residue 7
type MOD_RES
sequence X
description 4-carboxyglutamate => ECO:0000250|UniProtKB:P07231, ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI4

9) chain A
residue 11
type MOD_RES
sequence X
description 4-carboxyglutamate => ECO:0000250|UniProtKB:P07231, ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI4

10) chain A
residue 15
type MOD_RES
sequence X
description 4-carboxyglutamate => ECO:0000250|UniProtKB:P07231, ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI4

11) chain A
residue 10
type SITE
sequence A
description Important for activity (Pro and hydroxyPro) => ECO:0000305|PubMed:22594498, ECO:0000305|PubMed:26048991, ECO:0000305|PubMed:27981829
source Swiss-Prot : SWS_FT_FI3

12) chain A
residue 10
type MOD_RES
sequence A
description 4-hydroxyproline => ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI5

13) chain A
residue 18
type MOD_RES
sequence N
description Asparagine amide => ECO:0000250|UniProtKB:P07231, ECO:0000305|PubMed:22594498
source Swiss-Prot : SWS_FT_FI6

14) chain A
residue 1-15
type prosite
sequence GEXXLAXKAAXFARX
description CONANTOKIN Conantokin family signature. GEEElaEKAaEfARE
source prosite : PS60025


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