eF-site ID 5tbi-A PDB Code 5tbi Chain A click to enlarge Title Crystal structure of mouse CARM1 in complex with inhibitor LH1427 Classification TRANSFERASE Compound Histone-arginine methyltransferase CARM1 Source (CARM1_MOUSE) Sequence A:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYT Description Functional site 1) chain A residue 178 type sequence L description binding site for residue EDO A 501 source : AC1 2) chain A residue 398 type sequence G description binding site for residue EDO A 502 source : AC2 3) chain A residue 404 type sequence W description binding site for residue EDO A 504 source : AC3 4) chain A residue 153 type sequence F description binding site for residue EDO A 505 source : AC4 5) chain A residue 185 type sequence K description binding site for residue EDO A 506 source : AC5 6) chain A residue 187 type sequence K description binding site for residue EDO A 506 source : AC5 7) chain A residue 187 type sequence K description binding site for residue EDO A 506 source : AC5 8) chain A residue 150 type sequence Y description binding site for residue SAO A 507 source : AC6 9) chain A residue 151 type sequence F description binding site for residue SAO A 507 source : AC6 10) chain A residue 154 type sequence Y description binding site for residue SAO A 507 source : AC6 11) chain A residue 160 type sequence Q description binding site for residue SAO A 507 source : AC6 12) chain A residue 163 type sequence M description binding site for residue SAO A 507 source : AC6 13) chain A residue 169 type sequence R description binding site for residue SAO A 507 source : AC6 14) chain A residue 193 type sequence G description binding site for residue SAO A 507 source : AC6 15) chain A residue 194 type sequence C description binding site for residue SAO A 507 source : AC6 16) chain A residue 198 type sequence I description binding site for residue SAO A 507 source : AC6 17) chain A residue 199 type sequence L description binding site for residue SAO A 507 source : AC6 18) chain A residue 215 type sequence E description binding site for residue SAO A 507 source : AC6 19) chain A residue 216 type sequence A description binding site for residue SAO A 507 source : AC6 20) chain A residue 241 type sequence G description binding site for residue SAO A 507 source : AC6 21) chain A residue 242 type sequence K description binding site for residue SAO A 507 source : AC6 22) chain A residue 243 type sequence V description binding site for residue SAO A 507 source : AC6 23) chain A residue 244 type sequence E description binding site for residue SAO A 507 source : AC6 24) chain A residue 269 type sequence M description binding site for residue SAO A 507 source : AC6 25) chain A residue 272 type sequence S description binding site for residue SAO A 507 source : AC6 26) chain A residue 456 type sequence Q description binding site for residue PE8 B 501 source : AC7 27) chain A residue 463 type sequence K description binding site for residue PE8 B 501 source : AC7 28) chain A residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2

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