eF-site ID 5tbi-ABCD PDB Code 5tbi Chain A, B, C, D click to enlarge Title Crystal structure of mouse CARM1 in complex with inhibitor LH1427 Classification TRANSFERASE Compound Histone-arginine methyltransferase CARM1 Source (CARM1_MOUSE) Sequence A:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYT B:  RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQ RAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAV EASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDI IISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVH LAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIP FKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLT HWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIV AQVDQTGSKSSNLLDLKNPFFRY C:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYT D:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFR Description Functional site 1) chain A residue 178 type sequence L description binding site for residue EDO A 501 source : AC1 2) chain D residue 458 type sequence D description binding site for residue EDO A 501 source : AC1 3) chain A residue 398 type sequence G description binding site for residue EDO A 502 source : AC2 4) chain A residue 404 type sequence W description binding site for residue EDO A 504 source : AC3 5) chain A residue 153 type sequence F description binding site for residue EDO A 505 source : AC4 6) chain A residue 185 type sequence K description binding site for residue EDO A 506 source : AC5 7) chain A residue 187 type sequence K description binding site for residue EDO A 506 source : AC5 8) chain A residue 187 type sequence K description binding site for residue EDO A 506 source : AC5 9) chain A residue 150 type sequence Y description binding site for residue SAO A 507 source : AC6 10) chain A residue 151 type sequence F description binding site for residue SAO A 507 source : AC6 11) chain A residue 154 type sequence Y description binding site for residue SAO A 507 source : AC6 12) chain A residue 160 type sequence Q description binding site for residue SAO A 507 source : AC6 13) chain A residue 163 type sequence M description binding site for residue SAO A 507 source : AC6 14) chain A residue 169 type sequence R description binding site for residue SAO A 507 source : AC6 15) chain A residue 193 type sequence G description binding site for residue SAO A 507 source : AC6 16) chain A residue 194 type sequence C description binding site for residue SAO A 507 source : AC6 17) chain A residue 198 type sequence I description binding site for residue SAO A 507 source : AC6 18) chain A residue 199 type sequence L description binding site for residue SAO A 507 source : AC6 19) chain A residue 215 type sequence E description binding site for residue SAO A 507 source : AC6 20) chain A residue 216 type sequence A description binding site for residue SAO A 507 source : AC6 21) chain A residue 241 type sequence G description binding site for residue SAO A 507 source : AC6 22) chain A residue 242 type sequence K description binding site for residue SAO A 507 source : AC6 23) chain A residue 243 type sequence V description binding site for residue SAO A 507 source : AC6 24) chain A residue 244 type sequence E description binding site for residue SAO A 507 source : AC6 25) chain A residue 269 type sequence M description binding site for residue SAO A 507 source : AC6 26) chain A residue 272 type sequence S description binding site for residue SAO A 507 source : AC6 27) chain A residue 456 type sequence Q description binding site for residue PE8 B 501 source : AC7 28) chain A residue 463 type sequence K description binding site for residue PE8 B 501 source : AC7 29) chain B residue 136 type sequence S description binding site for residue PE8 B 501 source : AC7 30) chain B residue 240 type sequence P description binding site for residue PE8 B 501 source : AC7 31) chain B residue 244 type sequence E description binding site for residue PE8 B 501 source : AC7 32) chain B residue 245 type sequence E description binding site for residue PE8 B 501 source : AC7 33) chain B residue 251 type sequence Q description binding site for residue PE8 B 501 source : AC7 34) chain B residue 279 type sequence Y description binding site for residue PE8 B 501 source : AC7 35) chain B residue 267 type sequence E description binding site for residue EDO B 502 source : AC8 36) chain B residue 404 type sequence W description binding site for residue EDO B 503 source : AC9 37) chain B residue 150 type sequence Y description binding site for residue 78V B 504 source : AD1 38) chain B residue 151 type sequence F description binding site for residue 78V B 504 source : AD1 39) chain B residue 154 type sequence Y description binding site for residue 78V B 504 source : AD1 40) chain B residue 163 type sequence M description binding site for residue 78V B 504 source : AD1 41) chain B residue 193 type sequence G description binding site for residue 78V B 504 source : AD1 42) chain B residue 215 type sequence E description binding site for residue 78V B 504 source : AD1 43) chain B residue 216 type sequence A description binding site for residue 78V B 504 source : AD1 44) chain B residue 241 type sequence G description binding site for residue 78V B 504 source : AD1 45) chain B residue 242 type sequence K description binding site for residue 78V B 504 source : AD1 46) chain B residue 243 type sequence V description binding site for residue 78V B 504 source : AD1 47) chain B residue 244 type sequence E description binding site for residue 78V B 504 source : AD1 48) chain B residue 258 type sequence E description binding site for residue 78V B 504 source : AD1 49) chain B residue 260 type sequence M description binding site for residue 78V B 504 source : AD1 50) chain B residue 261 type sequence G description binding site for residue 78V B 504 source : AD1 51) chain B residue 262 type sequence Y description binding site for residue 78V B 504 source : AD1 52) chain B residue 267 type sequence E description binding site for residue 78V B 504 source : AD1 53) chain B residue 269 type sequence M description binding site for residue 78V B 504 source : AD1 54) chain B residue 272 type sequence S description binding site for residue 78V B 504 source : AD1 55) chain B residue 415 type sequence H description binding site for residue 78V B 504 source : AD1 56) chain B residue 416 type sequence W description binding site for residue 78V B 504 source : AD1 57) chain C residue 333 type sequence D description binding site for residue EDO C 501 source : AD2 58) chain C residue 336 type sequence F description binding site for residue EDO C 501 source : AD2 59) chain C residue 424 type sequence Q description binding site for residue EDO C 501 source : AD2 60) chain C residue 153 type sequence F description binding site for residue EDO C 502 source : AD3 61) chain C residue 267 type sequence E description binding site for residue EDO C 502 source : AD3 62) chain C residue 417 type sequence Y description binding site for residue EDO C 503 source : AD4 63) chain C residue 277 type sequence K description binding site for residue EDO C 504 source : AD5 64) chain C residue 280 type sequence L description binding site for residue EDO C 504 source : AD5 65) chain C residue 282 type sequence P description binding site for residue EDO C 504 source : AD5 66) chain C residue 404 type sequence W description binding site for residue EDO C 505 source : AD6 67) chain C residue 182 type sequence T description binding site for residue EDO C 506 source : AD7 68) chain C residue 187 type sequence K description binding site for residue EDO C 506 source : AD7 69) chain C residue 150 type sequence Y description binding site for residue SAO C 507 source : AD8 70) chain C residue 151 type sequence F description binding site for residue SAO C 507 source : AD8 71) chain C residue 154 type sequence Y description binding site for residue SAO C 507 source : AD8 72) chain C residue 160 type sequence Q description binding site for residue SAO C 507 source : AD8 73) chain C residue 163 type sequence M description binding site for residue SAO C 507 source : AD8 74) chain C residue 169 type sequence R description binding site for residue SAO C 507 source : AD8 75) chain C residue 193 type sequence G description binding site for residue SAO C 507 source : AD8 76) chain C residue 194 type sequence C description binding site for residue SAO C 507 source : AD8 77) chain C residue 198 type sequence I description binding site for residue SAO C 507 source : AD8 78) chain C residue 199 type sequence L description binding site for residue SAO C 507 source : AD8 79) chain C residue 215 type sequence E description binding site for residue SAO C 507 source : AD8 80) chain C residue 216 type sequence A description binding site for residue SAO C 507 source : AD8 81) chain C residue 241 type sequence G description binding site for residue SAO C 507 source : AD8 82) chain C residue 242 type sequence K description binding site for residue SAO C 507 source : AD8 83) chain C residue 243 type sequence V description binding site for residue SAO C 507 source : AD8 84) chain C residue 244 type sequence E description binding site for residue SAO C 507 source : AD8 85) chain C residue 258 type sequence E description binding site for residue SAO C 507 source : AD8 86) chain C residue 269 type sequence M description binding site for residue SAO C 507 source : AD8 87) chain C residue 272 type sequence S description binding site for residue SAO C 507 source : AD8 88) chain D residue 149 type sequence Q description binding site for residue EDO D 501 source : AD9 89) chain D residue 251 type sequence Q description binding site for residue EDO D 502 source : AE1 90) chain D residue 278 type sequence K description binding site for residue EDO D 502 source : AE1 91) chain D residue 279 type sequence Y description binding site for residue EDO D 502 source : AE1 92) chain D residue 393 type sequence D description binding site for residue EDO D 503 source : AE2 93) chain D residue 150 type sequence Y description binding site for residue 78V D 504 source : AE3 94) chain D residue 151 type sequence F description binding site for residue 78V D 504 source : AE3 95) chain D residue 154 type sequence Y description binding site for residue 78V D 504 source : AE3 96) chain D residue 163 type sequence M description binding site for residue 78V D 504 source : AE3 97) chain D residue 193 type sequence G description binding site for residue 78V D 504 source : AE3 98) chain D residue 215 type sequence E description binding site for residue 78V D 504 source : AE3 99) chain D residue 216 type sequence A description binding site for residue 78V D 504 source : AE3 100) chain D residue 241 type sequence G description binding site for residue 78V D 504 source : AE3 101) chain D residue 242 type sequence K description binding site for residue 78V D 504 source : AE3 102) chain D residue 243 type sequence V description binding site for residue 78V D 504 source : AE3 103) chain D residue 244 type sequence E description binding site for residue 78V D 504 source : AE3 104) chain D residue 258 type sequence E description binding site for residue 78V D 504 source : AE3 105) chain D residue 260 type sequence M description binding site for residue 78V D 504 source : AE3 106) chain D residue 261 type sequence G description binding site for residue 78V D 504 source : AE3 107) chain D residue 262 type sequence Y description binding site for residue 78V D 504 source : AE3 108) chain D residue 267 type sequence E description binding site for residue 78V D 504 source : AE3 109) chain D residue 269 type sequence M description binding site for residue 78V D 504 source : AE3 110) chain D residue 272 type sequence S description binding site for residue 78V D 504 source : AE3 111) chain D residue 415 type sequence H description binding site for residue 78V D 504 source : AE3 112) chain A residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 113) chain B residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 114) chain C residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 115) chain D residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 116) chain A residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 117) chain B residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 118) chain B residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 119) chain B residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 120) chain C residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 121) chain C residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 122) chain C residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 123) chain C residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 124) chain C residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 125) chain C residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 126) chain D residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 127) chain A residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 128) chain D residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 129) chain D residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 130) chain D residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 131) chain D residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 132) chain D residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 133) chain A residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 134) chain A residue 215 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 135) chain A residue 244 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 136) chain A residue 272 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 137) chain B residue 160 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 138) chain B residue 169 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 139) chain B residue 193 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17882261 source Swiss-Prot : SWS_FT_FI1 140) chain A residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3 141) chain B residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3 142) chain C residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3 143) chain D residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55 source Swiss-Prot : SWS_FT_FI3

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