eF-site ID 5t89-VWXY PDB Code 5t89 Chain V, W, X, Y click to enlarge Title Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6 Classification TRANSFERASE Compound Vascular endothelial growth factor A Source (VGFR1_HUMAN) Sequence V:  EVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCV PLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIG EMSFLQHNKCECRPKK W:  EVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCV PLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIG EMSFLQHNKCECRPKK X:  PELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKES ERLSIGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKTES AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEI GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI DQSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS PEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYT ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY PLGSRQILTCTAYGIPQPTIKWFWHPCNEESFILDADSNM GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIAS NKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCT VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT LNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT Y:  DPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE SERLSIGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSTES AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEI GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI DQSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS PEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYT ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY PLGSRQILTCTAYGIPQPTIKWFWHPCNHEESFILDADSN MGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIA SNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSC TVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT Description (1)  Vascular endothelial growth factor A, Vascular endothelial growth factor receptor 1 (E.C.2.7.10.1) Functional site 1) chain X residue 100 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain X residue 597 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain X residue 620 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain X residue 625 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain Y residue 100 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 6) chain Y residue 164 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 7) chain Y residue 196 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain Y residue 251 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain Y residue 323 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 10) chain Y residue 402 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain Y residue 417 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain X residue 164 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain Y residue 547 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain Y residue 597 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain Y residue 620 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain Y residue 625 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 17) chain X residue 196 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain X residue 251 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 19) chain X residue 323 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 20) chain X residue 402 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 21) chain X residue 417 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 22) chain X residue 547 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 23) chain V residue 49-61 type prosite sequence PSCVPLMRCGGCC description PDGF_1 Platelet-derived growth factor (PDGF) family signature. PSCVplmRCGGCC source prosite : PS00249

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