eF-site ID 5sva-A PDB Code 5sva Chain A click to enlarge Title Mediator-RNA Polymerase II Pre-Initiation Complex Classification TRANSCRIPTION, TRANSFERASE/DNA Compound DNA-directed RNA polymerase II subunit RPB1 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence A:  GQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMD ETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFG HIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELM RQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLV SRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVL STEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVP PPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHN GAPHHAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPV KSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLELD QVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGA KYVIRDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPV LFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADF DGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMG IVQDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPT PAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKD NGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVC AKLFGNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITET IAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVRFL NEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMS ACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVEN SYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLV KALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQS LDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGD LKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRR IIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRG KNEIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAF DWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTKK VTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKL IRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLH FSLQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKND LFVIWSEDNDEKLIIRCRVVAEEDHMLKKIENTMLENITL RGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNL SEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVY NVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSN TGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQM APIGTGAFDVMIDEESLVKYMP Description (1)  DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB4, DNA-directed RNA polymerases I, II, and III subunit RPABC1, DNA-directed RNA polymerases I, II, and III subunit RPABC2, DNA-directed RNA polymerase II subunit RPB7, DNA-directed RNA polymerases I, II, and III subunit RPABC3, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerases I, II, and III subunit RPABC4, Mediator of RNA polymerase II transcription subunit 6, Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, Mediator of RNA polymerase II transcription subunit 20, Mediator of RNA polymerase II transcription subunit 22, Mediator of RNA polymerase II transcription subunit 4, Mediator of RNA polymerase II transcription subunit 7, Mediator of RNA polymerase II transcription subunit 9, Mediator of RNA polymerase II transcription subunit 21, Mediator of RNA polymerase II transcription subunit 31, DNA repair helicase RAD3, DNA repair helicase RAD25, RNA polymerase II transcription factor B subunit 2, RNA polymerase II transcription factor B subunit 5, Transcription initiation factor IIB, Transcription initiation factor IIA large subunit, Transcription initiation factor IIA subunit 2, Transcription initiation factor IIF subunit alpha, Transcription initiation factor IIF subunit beta, Transcription initiation factor IIE subunit alpha, Transcription initiation factor IIE subunit beta, TATA-box-binding protein, Transcription initiation factor TFIID subunit 14/DNA Complex Functional site 1) chain A residue 107 type sequence C description binding site for residue ZN A 1801 source : AC1 2) chain A residue 110 type sequence C description binding site for residue ZN A 1801 source : AC1 3) chain A residue 148 type sequence C description binding site for residue ZN A 1801 source : AC1 4) chain A residue 167 type sequence C description binding site for residue ZN A 1801 source : AC1 5) chain A residue 67 type sequence C description binding site for residue ZN A 1802 source : AC2 6) chain A residue 70 type sequence C description binding site for residue ZN A 1802 source : AC2 7) chain A residue 77 type sequence C description binding site for residue ZN A 1802 source : AC2 8) chain A residue 80 type sequence H description binding site for residue ZN A 1802 source : AC2 9) chain A residue 481 type sequence D description binding site for residue MG A 1803 source : AC3 10) chain A residue 483 type sequence D description binding site for residue MG A 1803 source : AC3 11) chain A residue 485 type sequence D description binding site for residue MG A 1803 source : AC3 12) chain A residue 483 type SITE sequence D description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 13) chain A residue 485 type SITE sequence D description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 14) chain A residue 107 type SITE sequence C description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 15) chain A residue 110 type SITE sequence C description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 16) chain A residue 148 type SITE sequence C description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 17) chain A residue 167 type SITE sequence C description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 18) chain A residue 481 type SITE sequence D description Acylated histone binding => ECO:0000269|PubMed:26341557, ECO:0007744|PDB:5D7E source Swiss-Prot : SWS_FT_FI1 19) chain A residue 483 type catalytic sequence D description 788 source MCSA : MCSA1 20) chain A residue 485 type catalytic sequence D description 788 source MCSA : MCSA1

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