eF-site ID 5qie-A PDB Code 5qie Chain A click to enlarge Title PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of HAO1 in complex with Z2856434894 Classification OXIDOREDUCTASE Compound Hydroxyacid oxidase 1 Source (HAOX1_HUMAN) Sequence A:  RLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAA FSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQ RMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGP EALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPY LGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPDSGLAAYV AKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVK HGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVF LDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGV QDVLEILKEEFRLAMALSGCQNVKVIDKTLVRK Description Functional site 1) chain A residue 26 type sequence Y description binding site for residue FMN A 401 source : AC1 2) chain A residue 27 type sequence Y description binding site for residue FMN A 401 source : AC1 3) chain A residue 79 type sequence A description binding site for residue FMN A 401 source : AC1 4) chain A residue 80 type sequence T description binding site for residue FMN A 401 source : AC1 5) chain A residue 81 type sequence A description binding site for residue FMN A 401 source : AC1 6) chain A residue 108 type sequence S description binding site for residue FMN A 401 source : AC1 7) chain A residue 130 type sequence Q description binding site for residue FMN A 401 source : AC1 8) chain A residue 132 type sequence Y description binding site for residue FMN A 401 source : AC1 9) chain A residue 158 type sequence T description binding site for residue FMN A 401 source : AC1 10) chain A residue 236 type sequence K description binding site for residue FMN A 401 source : AC1 11) chain A residue 258 type sequence S description binding site for residue FMN A 401 source : AC1 12) chain A residue 260 type sequence H description binding site for residue FMN A 401 source : AC1 13) chain A residue 261 type sequence G description binding site for residue FMN A 401 source : AC1 14) chain A residue 263 type sequence R description binding site for residue FMN A 401 source : AC1 15) chain A residue 291 type sequence D description binding site for residue FMN A 401 source : AC1 16) chain A residue 292 type sequence G description binding site for residue FMN A 401 source : AC1 17) chain A residue 293 type sequence G description binding site for residue FMN A 401 source : AC1 18) chain A residue 295 type sequence R description binding site for residue FMN A 401 source : AC1 19) chain A residue 314 type sequence G description binding site for residue FMN A 401 source : AC1 20) chain A residue 315 type sequence R description binding site for residue FMN A 401 source : AC1 21) chain A residue 6 type sequence I description binding site for residue GWV A 402 source : AC2 22) chain A residue 166 type sequence N description binding site for residue GWV A 402 source : AC2 23) chain A residue 331 type sequence D description binding site for residue GWV A 402 source : AC2 24) chain A residue 258-264 type prosite sequence SNHGARQ description FMN_HYDROXY_ACID_DH_1 FMN-dependent alpha-hydroxy acid dehydrogenases active site. SNHGARQ source prosite : PS00557 25) chain A residue 230 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI10 26) chain A residue 194 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q9WU19 source Swiss-Prot : SWS_FT_FI9 27) chain A residue 260 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00683 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 260 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18215067, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDU source Swiss-Prot : SWS_FT_FI2 29) chain A residue 263 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18215067, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDU source Swiss-Prot : SWS_FT_FI2 30) chain A residue 132 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18215067, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDU source Swiss-Prot : SWS_FT_FI2 31) chain A residue 26 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18215067, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDU source Swiss-Prot : SWS_FT_FI2 32) chain A residue 130 type BINDING sequence Q description BINDING => ECO:0000255|PROSITE-ProRule:PRU00683, ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI5 33) chain A residue 167 type BINDING sequence R description BINDING => ECO:0000269|PubMed:18215067, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDU source Swiss-Prot : SWS_FT_FI6 34) chain A residue 291 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI7 35) chain A residue 314 type BINDING sequence G description BINDING => ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI7 36) chain A residue 258 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI7 37) chain A residue 184 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q9WU19 source Swiss-Prot : SWS_FT_FI8 38) chain A residue 79 type BINDING sequence A description BINDING => ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI3 39) chain A residue 236 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00683, ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI4 40) chain A residue 108 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00683, ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI4 41) chain A residue 158 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00683, ECO:0000269|PubMed:18215067, ECO:0000269|PubMed:20054120, ECO:0000269|Ref.11, ECO:0007744|PDB:2NZL, ECO:0007744|PDB:2RDT, ECO:0007744|PDB:2RDU, ECO:0007744|PDB:2RDW, ECO:0007744|PDB:2W0U source Swiss-Prot : SWS_FT_FI4

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