eF-site ID 5qdp-A
PDB Code 5qdp
Chain A

click to enlarge
Title PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000207a
Classification HYDROLASE
Compound Tyrosine-protein phosphatase non-receptor type 1
Source (PTN1_HUMAN)
Sequence A:  MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPSRVAKLPKN
KNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRS
YILTQGPLPNTVGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL
ENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRE
SGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF
IM
Description


Functional site

1) chain A
residue 45
type
sequence R
description binding site for residue JGA A 401
source : AC1

2) chain A
residue 118
type
sequence S
description binding site for residue JGA A 401
source : AC1

3) chain A
residue 196
type
sequence F
description binding site for residue JGA A 401
source : AC1

4) chain A
residue 236
type
sequence D
description binding site for residue JGA A 401
source : AC1

5) chain A
residue 281
type
sequence I
description binding site for residue JGA A 401
source : AC1

6) chain A
residue 282
type
sequence M
description binding site for residue JGA A 401
source : AC1

7) chain A
residue 54
type
sequence H
description binding site for residue TRS A 402
source : AC2

8) chain A
residue 128
type
sequence K
description binding site for residue TRS A 402
source : AC2

9) chain A
residue 129
type
sequence E
description binding site for residue TRS A 402
source : AC2

10) chain A
residue 130
type
sequence E
description binding site for residue TRS A 402
source : AC2

11) chain A
residue 181
type catalytic
sequence D
description 469
source MCSA : MCSA1

12) chain A
residue 215
type catalytic
sequence C
description 469
source MCSA : MCSA1

13) chain A
residue 221
type catalytic
sequence R
description 469
source MCSA : MCSA1

14) chain A
residue 222
type catalytic
sequence S
description 469
source MCSA : MCSA1

15) chain A
residue 262
type catalytic
sequence Q
description 469
source MCSA : MCSA1

16) chain A
residue 213-223
type prosite
sequence VHCSAGIGRSG
description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRSG
source prosite : PS00383

17) chain A
residue 215
type ACT_SITE
sequence C
description Phosphocysteine intermediate
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 215
type CROSSLNK
sequence C
description N,N-(cysteine-1,S-diyl)serine (Cys-Ser); in inhibited form => ECO:0000269|PubMed:12802338, ECO:0000269|PubMed:12802339
source Swiss-Prot : SWS_FT_FI10

19) chain A
residue 216
type CROSSLNK
sequence S
description N,N-(cysteine-1,S-diyl)serine (Cys-Ser); in inhibited form => ECO:0000269|PubMed:12802338, ECO:0000269|PubMed:12802339
source Swiss-Prot : SWS_FT_FI10

20) chain A
residue 181
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 215
type BINDING
sequence C
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

22) chain A
residue 262
type BINDING
sequence Q
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

23) chain A
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0000269|PubMed:2546149
source Swiss-Prot : SWS_FT_FI4

24) chain A
residue 20
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:15592455
source Swiss-Prot : SWS_FT_FI5

25) chain A
residue 50
type MOD_RES
sequence S
description Phosphoserine; by PKB/AKT1, CLK1 and CLK2 => ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:11579209, ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI6

26) chain A
residue 66
type MOD_RES
sequence Y
description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:9355745
source Swiss-Prot : SWS_FT_FI7

27) chain A
residue 215
type MOD_RES
sequence C
description S-nitrosocysteine; in reversibly inhibited form => ECO:0000269|PubMed:22169477
source Swiss-Prot : SWS_FT_FI8

28) chain A
residue 242
type MOD_RES
sequence S
description Phosphoserine; by CLK1 and CLK2 => ECO:0000269|PubMed:10480872
source Swiss-Prot : SWS_FT_FI9

29) chain A
residue 243
type MOD_RES
sequence S
description Phosphoserine; by CLK1 and CLK2 => ECO:0000269|PubMed:10480872
source Swiss-Prot : SWS_FT_FI9


Display surface

Download
Links