eF-site ID 5q0c-E PDB Code 5q0c Chain E click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase isozyme 2 Source (F16P2_HUMAN) Sequence E:  TDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSA VRKAGLAHLYGIAGSVNVTGDEVKKLDVLSNSLVINMLQS SYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNID CLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALY GSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGK IYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGS MVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYI IEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEY LTCVQKNQ Description (1)  Fructose-1,6-bisphosphatase isozyme 2 (E.C.3.1.3.11) Functional site 1) chain E residue 19 type ligand sequence M description binding site for residue 96G E 401 source : AC9 2) chain E residue 21 type ligand sequence K description binding site for residue 96G E 401 source : AC9 3) chain E residue 22 type ligand sequence G description binding site for residue 96G E 401 source : AC9 4) chain E residue 23 type ligand sequence R description binding site for residue 96G E 401 source : AC9 5) chain E residue 25 type ligand sequence A description binding site for residue 96G E 401 source : AC9 6) chain E residue 27 type ligand sequence G description binding site for residue 96G E 401 source : AC9 7) chain E residue 29 type ligand sequence G description binding site for residue 96G E 401 source : AC9 8) chain E residue 30 type ligand sequence E description binding site for residue 96G E 401 source : AC9 9) chain E residue 31 type ligand sequence L description binding site for residue 96G E 401 source : AC9 10) chain E residue 32 type ligand sequence T description binding site for residue 96G E 401 source : AC9 11) chain E residue 178 type ligand sequence T description binding site for residue 96G E 401 source : AC9 12) chain E residue 180 type ligand sequence Q description binding site for residue 96G E 401 source : AC9 13) chain E residue 122 type ligand sequence D description binding site for residue FDP E 402 source : AD1 14) chain E residue 123 type ligand sequence G description binding site for residue FDP E 402 source : AD1 15) chain E residue 124 type ligand sequence S description binding site for residue FDP E 402 source : AD1 16) chain E residue 125 type ligand sequence S description binding site for residue FDP E 402 source : AD1 17) chain E residue 213 type ligand sequence N description binding site for residue FDP E 402 source : AD1 18) chain E residue 216 type ligand sequence Y description binding site for residue FDP E 402 source : AD1 19) chain E residue 245 type ligand sequence Y description binding site for residue FDP E 402 source : AD1 20) chain E residue 247 type ligand sequence G description binding site for residue FDP E 402 source : AD1 21) chain E residue 248 type ligand sequence S description binding site for residue FDP E 402 source : AD1 22) chain E residue 249 type ligand sequence M description binding site for residue FDP E 402 source : AD1 23) chain E residue 265 type ligand sequence Y description binding site for residue FDP E 402 source : AD1 24) chain E residue 275 type ligand sequence K description binding site for residue FDP E 402 source : AD1 25) chain E residue 281 type ligand sequence E description binding site for residue FDP E 402 source : AD1 26) chain E residue 244 type ligand sequence R description binding site for residue FDP F 402 source : AD3 27) chain E residue 18-19 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence VM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_E_401 28) chain E residue 21-32 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence KGRQAKGTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_E_401 29) chain E residue 114 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_E_401 30) chain E residue 178 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence T description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_E_401 31) chain E residue 180 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence Q description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_E_401 32) chain E residue 28-29 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_G_401 33) chain E residue 32-33 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence TQ description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_G_401 34) chain E residue 119 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence D description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 35) chain E residue 122-126 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence DGSSN description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 36) chain E residue 213 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence N description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 37) chain E residue 216 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence Y description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 38) chain E residue 245 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence Y description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 39) chain E residue 247-250 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence GSMV description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 40) chain E residue 263 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence F description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 41) chain E residue 265 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence Y description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 42) chain E residue 275-276 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence KL description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 43) chain E residue 281 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence E description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_E_402 44) chain E residue 244 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence R description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_F_402

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