eF-site ID 5q0c-D PDB Code 5q0c Chain D click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase isozyme 2 Source (F16P2_HUMAN) Sequence D:  TDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSA VRKAGLAHLYGIAGSVNVKLDVLSNSLVINMLQSSYSTCV LVSEENKDAIITAKEKRGKYVVCFDPLDGSSNIDCLASIG TIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLV ALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNE GYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVH RTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGG LATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQK NQ Description (1)  Fructose-1,6-bisphosphatase isozyme 2 (E.C.3.1.3.11) Functional site 1) chain D residue 29 type ligand sequence G description binding site for residue 96G B 401 source : AC3 2) chain D residue 244 type ligand sequence R description binding site for residue FDP C 402 source : AC6 3) chain D residue 21 type ligand sequence K description binding site for residue 96G D 401 source : AC7 4) chain D residue 22 type ligand sequence G description binding site for residue 96G D 401 source : AC7 5) chain D residue 23 type ligand sequence R description binding site for residue 96G D 401 source : AC7 6) chain D residue 25 type ligand sequence A description binding site for residue 96G D 401 source : AC7 7) chain D residue 27 type ligand sequence G description binding site for residue 96G D 401 source : AC7 8) chain D residue 28 type ligand sequence T description binding site for residue 96G D 401 source : AC7 9) chain D residue 29 type ligand sequence G description binding site for residue 96G D 401 source : AC7 10) chain D residue 30 type ligand sequence E description binding site for residue 96G D 401 source : AC7 11) chain D residue 31 type ligand sequence L description binding site for residue 96G D 401 source : AC7 12) chain D residue 32 type ligand sequence T description binding site for residue 96G D 401 source : AC7 13) chain D residue 178 type ligand sequence T description binding site for residue 96G D 401 source : AC7 14) chain D residue 180 type ligand sequence Q description binding site for residue 96G D 401 source : AC7 15) chain D residue 122 type ligand sequence D description binding site for residue FDP D 402 source : AC8 16) chain D residue 123 type ligand sequence G description binding site for residue FDP D 402 source : AC8 17) chain D residue 124 type ligand sequence S description binding site for residue FDP D 402 source : AC8 18) chain D residue 125 type ligand sequence S description binding site for residue FDP D 402 source : AC8 19) chain D residue 213 type ligand sequence N description binding site for residue FDP D 402 source : AC8 20) chain D residue 216 type ligand sequence Y description binding site for residue FDP D 402 source : AC8 21) chain D residue 245 type ligand sequence Y description binding site for residue FDP D 402 source : AC8 22) chain D residue 247 type ligand sequence G description binding site for residue FDP D 402 source : AC8 23) chain D residue 248 type ligand sequence S description binding site for residue FDP D 402 source : AC8 24) chain D residue 249 type ligand sequence M description binding site for residue FDP D 402 source : AC8 25) chain D residue 265 type ligand sequence Y description binding site for residue FDP D 402 source : AC8 26) chain D residue 275 type ligand sequence K description binding site for residue FDP D 402 source : AC8 27) chain D residue 281 type ligand sequence E description binding site for residue FDP D 402 source : AC8 28) chain D residue 28-29 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_B_401 29) chain D residue 32-33 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence TQ description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_B_401 30) chain D residue 18-19 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence VM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 31) chain D residue 21-23 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence KGR description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 32) chain D residue 25 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence A description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 33) chain D residue 27-32 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence GTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 34) chain D residue 114 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 35) chain D residue 178 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence T description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 36) chain D residue 180 type binding ligand 96G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide sequence Q description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site source pdb_hetatom : 96G_5q0c_D_401 37) chain D residue 244 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence R description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_C_402 38) chain D residue 119 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence D description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 39) chain D residue 122-126 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence DGSSN description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 40) chain D residue 213 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence N description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 41) chain D residue 216 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence Y description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 42) chain D residue 245 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence Y description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 43) chain D residue 247-249 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence GSM description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 44) chain D residue 263 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence F description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 45) chain D residue 265 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence Y description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 46) chain D residue 275-276 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence KL description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402 47) chain D residue 281 type binding ligand FDP: FRUCTOSE-2,6-DIPHOSPHATE sequence E description FRUCTOSE-2,6-DIPHOSPHATE binding site source pdb_hetatom : FDP_5q0c_D_402

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