eF-site ID 5q0c-A PDB Code 5q0c Chain A click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase isozyme 2 Source (F16P2_HUMAN) Sequence A:  TDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSA VRKAGLAHLYGIAGSVNVTGDEVKKLDVLSNSLVINMLQS SYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNID CLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALY GSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGK IYSLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGS MVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYI IEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEY LTCVQKNQ Description Functional site 1) chain A residue 274-286 type prosite sequence GKLRLLYECNPVA description FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA source prosite : PS00124 2) chain A residue 18 type BINDING sequence V description BINDING => ECO:0000269|PubMed:22120740 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 28 type BINDING sequence T description BINDING => ECO:0000269|PubMed:22120740 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 113 type BINDING sequence K description BINDING => ECO:0000269|PubMed:22120740 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 141 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22120740 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 69 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 7) chain A residue 281 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 8) chain A residue 98 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 9) chain A residue 119 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 10) chain A residue 121 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 11) chain A residue 122 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 12) chain A residue 213 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 13) chain A residue 245 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 14) chain A residue 265 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 15) chain A residue 275 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 16) chain A residue 33 type SITE sequence Q description Important for the conversion from active R-state to inactive T-state in the presence of AMP source Swiss-Prot : SWS_FT_FI3 17) chain A residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1N1 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 219 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1N1 source Swiss-Prot : SWS_FT_FI4

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