eF-site ID 5q0b-D PDB Code 5q0b Chain D click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-3-methyl-1,2-thiazol-5-yl)-3-(3-methylphenyl)sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description (1)  Fructose-1,6-bisphosphatase 1 Functional site 1) chain D residue 27 type ligand sequence T description binding site for residue 96J B 401 source : AC2 2) chain D residue 17 type ligand sequence V description binding site for residue 96J D 401 source : AC4 3) chain D residue 18 type ligand sequence M description binding site for residue 96J D 401 source : AC4 4) chain D residue 21 type ligand sequence G description binding site for residue 96J D 401 source : AC4 5) chain D residue 22 type ligand sequence R description binding site for residue 96J D 401 source : AC4 6) chain D residue 24 type ligand sequence A description binding site for residue 96J D 401 source : AC4 7) chain D residue 26 type ligand sequence G description binding site for residue 96J D 401 source : AC4 8) chain D residue 27 type ligand sequence T description binding site for residue 96J D 401 source : AC4 9) chain D residue 28 type ligand sequence G description binding site for residue 96J D 401 source : AC4 10) chain D residue 29 type ligand sequence E description binding site for residue 96J D 401 source : AC4 11) chain D residue 30 type ligand sequence L description binding site for residue 96J D 401 source : AC4 12) chain D residue 31 type ligand sequence T description binding site for residue 96J D 401 source : AC4 13) chain D residue 18 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence M description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_B_401 14) chain D residue 26-28 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence GTG description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_B_401 15) chain D residue 17-18 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence VM description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_D_401 16) chain D residue 20-22 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence EGR description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_D_401 17) chain D residue 24-31 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence ARGTGELT description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_D_401 18) chain D residue 34 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence L description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_D_401 19) chain D residue 113 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence Y description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_D_401 20) chain D residue 177 type binding ligand 96J: N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide sequence M description N-[(4-bromo-3-methyl-1,2-thiazol-5-yl)carbamoyl]-3-methylbenzene-1-sulfonamide binding site source pdb_hetatom : 96J_5q0b_D_401

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