eF-site ID 5q08-F
PDB Code 5q08
Chain F

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Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(1-benzothiophen-3-ylsulfonyl)-3-(5-bromo-1,3-thiazol-2-yl)urea
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence F:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description (1)  Fructose-1,6-bisphosphatase 1


Functional site

1) chain F
residue 17
type
ligand
sequence V
description binding site for residue 967 F 401
source : AC6

2) chain F
residue 18
type
ligand
sequence M
description binding site for residue 967 F 401
source : AC6

3) chain F
residue 21
type
ligand
sequence G
description binding site for residue 967 F 401
source : AC6

4) chain F
residue 22
type
ligand
sequence R
description binding site for residue 967 F 401
source : AC6

5) chain F
residue 24
type
ligand
sequence A
description binding site for residue 967 F 401
source : AC6

6) chain F
residue 26
type
ligand
sequence G
description binding site for residue 967 F 401
source : AC6

7) chain F
residue 27
type
ligand
sequence T
description binding site for residue 967 F 401
source : AC6

8) chain F
residue 28
type
ligand
sequence G
description binding site for residue 967 F 401
source : AC6

9) chain F
residue 29
type
ligand
sequence E
description binding site for residue 967 F 401
source : AC6

10) chain F
residue 30
type
ligand
sequence L
description binding site for residue 967 F 401
source : AC6

11) chain F
residue 31
type
ligand
sequence T
description binding site for residue 967 F 401
source : AC6

12) chain F
residue 27
type
ligand
sequence T
description binding site for residue 967 H 401
source : AC8

13) chain F
residue 28
type
ligand
sequence G
description binding site for residue 967 H 401
source : AC8

14) chain F
residue 17-18
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence VM
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_F_401

15) chain F
residue 20-22
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence EGR
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_F_401

16) chain F
residue 24-31
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence ARGTGELT
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_F_401

17) chain F
residue 113
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence Y
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_F_401

18) chain F
residue 177
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence M
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_F_401

19) chain F
residue 27-28
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence TG
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_H_401

20) chain F
residue 31-32
type binding
ligand 967: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide
sequence TQ
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-1-benzothiophene-3-sulfonamide binding site
source pdb_hetatom : 967_5q08_H_401


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