eF-site ID 5q07-B PDB Code 5q07 Chain B click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-6-morpholin-4-ylpyridin-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea Classification HYDROLASE/HYDROLASE inhibitor Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain B residue 17 type sequence V description binding site for residue 95Y B 401 source : AC2 2) chain B residue 20 type sequence E description binding site for residue 95Y B 401 source : AC2 3) chain B residue 21 type sequence G description binding site for residue 95Y B 401 source : AC2 4) chain B residue 22 type sequence R description binding site for residue 95Y B 401 source : AC2 5) chain B residue 24 type sequence A description binding site for residue 95Y B 401 source : AC2 6) chain B residue 25 type sequence R description binding site for residue 95Y B 401 source : AC2 7) chain B residue 26 type sequence G description binding site for residue 95Y B 401 source : AC2 8) chain B residue 27 type sequence T description binding site for residue 95Y B 401 source : AC2 9) chain B residue 28 type sequence G description binding site for residue 95Y B 401 source : AC2 10) chain B residue 29 type sequence E description binding site for residue 95Y B 401 source : AC2 11) chain B residue 30 type sequence L description binding site for residue 95Y B 401 source : AC2 12) chain B residue 31 type sequence T description binding site for residue 95Y B 401 source : AC2 13) chain B residue 160 type sequence V description binding site for residue 95Y B 401 source : AC2 14) chain B residue 26 type sequence G description binding site for residue 95Y D 401 source : AC4 15) chain B residue 27 type sequence T description binding site for residue 95Y D 401 source : AC4

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