eF-site ID 5q06-ABCD PDB Code 5q06 Chain A, B, C, D click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS C:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKKLDVLSNDLVMNMLKSSFATCVLVSE EDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFG IYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAM DCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAK DFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV YGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATT GKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description (1)  Fructose-1,6-bisphosphatase 1 Functional site 1) chain A residue 16 type ligand sequence F description binding site for residue 95V A 401 source : AC1 2) chain A residue 20 type ligand sequence E description binding site for residue 95V A 401 source : AC1 3) chain A residue 21 type ligand sequence G description binding site for residue 95V A 401 source : AC1 4) chain A residue 22 type ligand sequence R description binding site for residue 95V A 401 source : AC1 5) chain A residue 26 type ligand sequence G description binding site for residue 95V A 401 source : AC1 6) chain A residue 27 type ligand sequence T description binding site for residue 95V A 401 source : AC1 7) chain A residue 28 type ligand sequence G description binding site for residue 95V A 401 source : AC1 8) chain A residue 29 type ligand sequence E description binding site for residue 95V A 401 source : AC1 9) chain A residue 30 type ligand sequence L description binding site for residue 95V A 401 source : AC1 10) chain A residue 31 type ligand sequence T description binding site for residue 95V A 401 source : AC1 11) chain A residue 177 type ligand sequence M description binding site for residue 95V A 401 source : AC1 12) chain A residue 179 type ligand sequence C description binding site for residue 95V A 401 source : AC1 13) chain B residue 16 type ligand sequence F description binding site for residue 95V B 401 source : AC2 14) chain B residue 20 type ligand sequence E description binding site for residue 95V B 401 source : AC2 15) chain B residue 21 type ligand sequence G description binding site for residue 95V B 401 source : AC2 16) chain B residue 22 type ligand sequence R description binding site for residue 95V B 401 source : AC2 17) chain B residue 26 type ligand sequence G description binding site for residue 95V B 401 source : AC2 18) chain B residue 27 type ligand sequence T description binding site for residue 95V B 401 source : AC2 19) chain B residue 28 type ligand sequence G description binding site for residue 95V B 401 source : AC2 20) chain B residue 29 type ligand sequence E description binding site for residue 95V B 401 source : AC2 21) chain B residue 30 type ligand sequence L description binding site for residue 95V B 401 source : AC2 22) chain B residue 31 type ligand sequence T description binding site for residue 95V B 401 source : AC2 23) chain B residue 177 type ligand sequence M description binding site for residue 95V B 401 source : AC2 24) chain B residue 179 type ligand sequence C description binding site for residue 95V B 401 source : AC2 25) chain A residue 27 type ligand sequence T description binding site for residue 95V C 401 source : AC3 26) chain C residue 16 type ligand sequence F description binding site for residue 95V C 401 source : AC3 27) chain C residue 18 type ligand sequence M description binding site for residue 95V C 401 source : AC3 28) chain C residue 20 type ligand sequence E description binding site for residue 95V C 401 source : AC3 29) chain C residue 21 type ligand sequence G description binding site for residue 95V C 401 source : AC3 30) chain C residue 22 type ligand sequence R description binding site for residue 95V C 401 source : AC3 31) chain C residue 24 type ligand sequence A description binding site for residue 95V C 401 source : AC3 32) chain C residue 26 type ligand sequence G description binding site for residue 95V C 401 source : AC3 33) chain C residue 27 type ligand sequence T description binding site for residue 95V C 401 source : AC3 34) chain C residue 28 type ligand sequence G description binding site for residue 95V C 401 source : AC3 35) chain C residue 29 type ligand sequence E description binding site for residue 95V C 401 source : AC3 36) chain C residue 30 type ligand sequence L description binding site for residue 95V C 401 source : AC3 37) chain C residue 31 type ligand sequence T description binding site for residue 95V C 401 source : AC3 38) chain C residue 177 type ligand sequence M description binding site for residue 95V C 401 source : AC3 39) chain C residue 179 type ligand sequence C description binding site for residue 95V C 401 source : AC3 40) chain B residue 27 type ligand sequence T description binding site for residue 95V D 401 source : AC4 41) chain B residue 28 type ligand sequence G description binding site for residue 95V D 401 source : AC4 42) chain D residue 16 type ligand sequence F description binding site for residue 95V D 401 source : AC4 43) chain D residue 18 type ligand sequence M description binding site for residue 95V D 401 source : AC4 44) chain D residue 20 type ligand sequence E description binding site for residue 95V D 401 source : AC4 45) chain D residue 21 type ligand sequence G description binding site for residue 95V D 401 source : AC4 46) chain D residue 22 type ligand sequence R description binding site for residue 95V D 401 source : AC4 47) chain D residue 26 type ligand sequence G description binding site for residue 95V D 401 source : AC4 48) chain D residue 28 type ligand sequence G description binding site for residue 95V D 401 source : AC4 49) chain D residue 29 type ligand sequence E description binding site for residue 95V D 401 source : AC4 50) chain D residue 30 type ligand sequence L description binding site for residue 95V D 401 source : AC4 51) chain D residue 31 type ligand sequence T description binding site for residue 95V D 401 source : AC4 52) chain D residue 177 type ligand sequence M description binding site for residue 95V D 401 source : AC4 53) chain D residue 179 type ligand sequence C description binding site for residue 95V D 401 source : AC4 54) chain A residue 16-18 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence FVM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 55) chain A residue 20-22 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence EGR description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 56) chain A residue 24-31 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence ARGTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 57) chain A residue 113 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 58) chain A residue 175 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence L description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 59) chain A residue 177 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence M description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 60) chain A residue 179 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence C description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 61) chain C residue 27-28 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 62) chain C residue 31 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence T description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_A_401 63) chain A residue 27-28 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 64) chain A residue 31-32 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TQ description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 65) chain C residue 16-18 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence FVM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 66) chain C residue 20-22 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence EGR description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 67) chain C residue 24-31 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence ARGTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 68) chain C residue 113 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 69) chain C residue 175 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence L description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 70) chain C residue 177 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence M description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 71) chain C residue 179 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence C description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_C_401 72) chain B residue 16-18 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence FVM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 73) chain B residue 20-22 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence EGR description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 74) chain B residue 24-31 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence ARGTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 75) chain B residue 113 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 76) chain B residue 177 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence M description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 77) chain B residue 179 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence C description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 78) chain D residue 27-28 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 79) chain D residue 31-32 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TQ description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_B_401 80) chain B residue 27-28 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 81) chain B residue 31-32 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence TQ description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 82) chain D residue 16-18 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence FVM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 83) chain D residue 20-22 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence EGR description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 84) chain D residue 24-31 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence ARGTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 85) chain D residue 113 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 86) chain D residue 177 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence M description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401 87) chain D residue 179 type binding ligand 95V: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide sequence C description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-4-(2-methyl-1,3-thiazol-4-yl)benzene-1-sulfonamide binding site source pdb_hetatom : 95V_5q06_D_401

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