eF-site ID 5q06-ABCD PDB Code 5q06 Chain A, B, C, D click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS C:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKKLDVLSNDLVMNMLKSSFATCVLVSE EDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFG IYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAM DCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAK DFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV YGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATT GKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain A residue 16 type sequence F description binding site for residue 95V A 401 source : AC1 2) chain A residue 20 type sequence E description binding site for residue 95V A 401 source : AC1 3) chain A residue 21 type sequence G description binding site for residue 95V A 401 source : AC1 4) chain A residue 22 type sequence R description binding site for residue 95V A 401 source : AC1 5) chain A residue 26 type sequence G description binding site for residue 95V A 401 source : AC1 6) chain A residue 27 type sequence T description binding site for residue 95V A 401 source : AC1 7) chain A residue 28 type sequence G description binding site for residue 95V A 401 source : AC1 8) chain A residue 29 type sequence E description binding site for residue 95V A 401 source : AC1 9) chain A residue 30 type sequence L description binding site for residue 95V A 401 source : AC1 10) chain A residue 31 type sequence T description binding site for residue 95V A 401 source : AC1 11) chain A residue 177 type sequence M description binding site for residue 95V A 401 source : AC1 12) chain A residue 179 type sequence C description binding site for residue 95V A 401 source : AC1 13) chain B residue 16 type sequence F description binding site for residue 95V B 401 source : AC2 14) chain B residue 20 type sequence E description binding site for residue 95V B 401 source : AC2 15) chain B residue 21 type sequence G description binding site for residue 95V B 401 source : AC2 16) chain B residue 22 type sequence R description binding site for residue 95V B 401 source : AC2 17) chain B residue 26 type sequence G description binding site for residue 95V B 401 source : AC2 18) chain B residue 27 type sequence T description binding site for residue 95V B 401 source : AC2 19) chain B residue 28 type sequence G description binding site for residue 95V B 401 source : AC2 20) chain B residue 29 type sequence E description binding site for residue 95V B 401 source : AC2 21) chain B residue 30 type sequence L description binding site for residue 95V B 401 source : AC2 22) chain B residue 31 type sequence T description binding site for residue 95V B 401 source : AC2 23) chain B residue 177 type sequence M description binding site for residue 95V B 401 source : AC2 24) chain B residue 179 type sequence C description binding site for residue 95V B 401 source : AC2 25) chain A residue 27 type sequence T description binding site for residue 95V C 401 source : AC3 26) chain C residue 16 type sequence F description binding site for residue 95V C 401 source : AC3 27) chain C residue 18 type sequence M description binding site for residue 95V C 401 source : AC3 28) chain C residue 20 type sequence E description binding site for residue 95V C 401 source : AC3 29) chain C residue 21 type sequence G description binding site for residue 95V C 401 source : AC3 30) chain C residue 22 type sequence R description binding site for residue 95V C 401 source : AC3 31) chain C residue 24 type sequence A description binding site for residue 95V C 401 source : AC3 32) chain C residue 26 type sequence G description binding site for residue 95V C 401 source : AC3 33) chain C residue 27 type sequence T description binding site for residue 95V C 401 source : AC3 34) chain C residue 28 type sequence G description binding site for residue 95V C 401 source : AC3 35) chain C residue 29 type sequence E description binding site for residue 95V C 401 source : AC3 36) chain C residue 30 type sequence L description binding site for residue 95V C 401 source : AC3 37) chain C residue 31 type sequence T description binding site for residue 95V C 401 source : AC3 38) chain C residue 177 type sequence M description binding site for residue 95V C 401 source : AC3 39) chain C residue 179 type sequence C description binding site for residue 95V C 401 source : AC3 40) chain B residue 27 type sequence T description binding site for residue 95V D 401 source : AC4 41) chain B residue 28 type sequence G description binding site for residue 95V D 401 source : AC4 42) chain D residue 16 type sequence F description binding site for residue 95V D 401 source : AC4 43) chain D residue 18 type sequence M description binding site for residue 95V D 401 source : AC4 44) chain D residue 20 type sequence E description binding site for residue 95V D 401 source : AC4 45) chain D residue 21 type sequence G description binding site for residue 95V D 401 source : AC4 46) chain D residue 22 type sequence R description binding site for residue 95V D 401 source : AC4 47) chain D residue 26 type sequence G description binding site for residue 95V D 401 source : AC4 48) chain D residue 28 type sequence G description binding site for residue 95V D 401 source : AC4 49) chain D residue 29 type sequence E description binding site for residue 95V D 401 source : AC4 50) chain D residue 30 type sequence L description binding site for residue 95V D 401 source : AC4 51) chain D residue 31 type sequence T description binding site for residue 95V D 401 source : AC4 52) chain D residue 177 type sequence M description binding site for residue 95V D 401 source : AC4 53) chain D residue 179 type sequence C description binding site for residue 95V D 401 source : AC4 54) chain A residue 273-285 type prosite sequence GKLRLLYECNPMA description FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA source prosite : PS00124

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