eF-site ID 5q05-G PDB Code 5q05 Chain G click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea Classification Hydrolase/Hydrolase Inhibitor Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence G:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain G residue 27 type sequence T description binding site for residue 95S E 401 source : AC5 2) chain G residue 17 type sequence V description binding site for residue 95S G 401 source : AC7 3) chain G residue 18 type sequence M description binding site for residue 95S G 401 source : AC7 4) chain G residue 21 type sequence G description binding site for residue 95S G 401 source : AC7 5) chain G residue 22 type sequence R description binding site for residue 95S G 401 source : AC7 6) chain G residue 26 type sequence G description binding site for residue 95S G 401 source : AC7 7) chain G residue 27 type sequence T description binding site for residue 95S G 401 source : AC7 8) chain G residue 28 type sequence G description binding site for residue 95S G 401 source : AC7 9) chain G residue 29 type sequence E description binding site for residue 95S G 401 source : AC7 10) chain G residue 30 type sequence L description binding site for residue 95S G 401 source : AC7 11) chain G residue 31 type sequence T description binding site for residue 95S G 401 source : AC7

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