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eF-site ID
|
5q05-E |
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PDB Code
|
5q05 |
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Chain
|
E |
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click to enlarge
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Title
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Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea |
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Classification
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Hydrolase/Hydrolase Inhibitor |
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Compound
|
Fructose-1,6-bisphosphatase 1 |
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Source
|
(Q2TU34_HUMAN) |
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Sequence
|
E: |
DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS
EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF
GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA
MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA
KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL
VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT
TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
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Description
|
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Functional site
|
|
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1)
|
chain |
E |
| residue |
17 |
| type |
|
| sequence |
V
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
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2)
|
chain |
E |
| residue |
21 |
| type |
|
| sequence |
G
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
3)
|
chain |
E |
| residue |
22 |
| type |
|
| sequence |
R
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
4)
|
chain |
E |
| residue |
26 |
| type |
|
| sequence |
G
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
5)
|
chain |
E |
| residue |
28 |
| type |
|
| sequence |
G
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
6)
|
chain |
E |
| residue |
29 |
| type |
|
| sequence |
E
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
7)
|
chain |
E |
| residue |
30 |
| type |
|
| sequence |
L
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
8)
|
chain |
E |
| residue |
31 |
| type |
|
| sequence |
T
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
9)
|
chain |
E |
| residue |
178 |
| type |
|
| sequence |
D
|
| description |
binding site for residue 95S E 401
|
| source |
: AC5
|
|
|
10)
|
chain |
E |
| residue |
27 |
| type |
|
| sequence |
T
|
| description |
binding site for residue 95S G 401
|
| source |
: AC7
|
|
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