eF-site ID 5q04-ABCDEFGH PDB Code 5q04 Chain A, B, C, D, E, F, G, H click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS C:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS E:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS F:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS G:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS H:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain A residue 17 type sequence V description binding site for residue 95P A 401 source : AC1 2) chain A residue 18 type sequence M description binding site for residue 95P A 401 source : AC1 3) chain A residue 21 type sequence G description binding site for residue 95P A 401 source : AC1 4) chain A residue 26 type sequence G description binding site for residue 95P A 401 source : AC1 5) chain A residue 27 type sequence T description binding site for residue 95P A 401 source : AC1 6) chain A residue 28 type sequence G description binding site for residue 95P A 401 source : AC1 7) chain A residue 29 type sequence E description binding site for residue 95P A 401 source : AC1 8) chain A residue 30 type sequence L description binding site for residue 95P A 401 source : AC1 9) chain A residue 31 type sequence T description binding site for residue 95P A 401 source : AC1 10) chain A residue 177 type sequence M description binding site for residue 95P A 401 source : AC1 11) chain B residue 17 type sequence V description binding site for residue 95P B 401 source : AC2 12) chain B residue 18 type sequence M description binding site for residue 95P B 401 source : AC2 13) chain B residue 21 type sequence G description binding site for residue 95P B 401 source : AC2 14) chain B residue 22 type sequence R description binding site for residue 95P B 401 source : AC2 15) chain B residue 24 type sequence A description binding site for residue 95P B 401 source : AC2 16) chain B residue 26 type sequence G description binding site for residue 95P B 401 source : AC2 17) chain B residue 27 type sequence T description binding site for residue 95P B 401 source : AC2 18) chain B residue 28 type sequence G description binding site for residue 95P B 401 source : AC2 19) chain B residue 29 type sequence E description binding site for residue 95P B 401 source : AC2 20) chain B residue 30 type sequence L description binding site for residue 95P B 401 source : AC2 21) chain B residue 31 type sequence T description binding site for residue 95P B 401 source : AC2 22) chain B residue 177 type sequence M description binding site for residue 95P B 401 source : AC2 23) chain A residue 27 type sequence T description binding site for residue 95P C 401 source : AC3 24) chain C residue 18 type sequence M description binding site for residue 95P C 401 source : AC3 25) chain C residue 21 type sequence G description binding site for residue 95P C 401 source : AC3 26) chain C residue 22 type sequence R description binding site for residue 95P C 401 source : AC3 27) chain C residue 24 type sequence A description binding site for residue 95P C 401 source : AC3 28) chain C residue 26 type sequence G description binding site for residue 95P C 401 source : AC3 29) chain C residue 27 type sequence T description binding site for residue 95P C 401 source : AC3 30) chain C residue 28 type sequence G description binding site for residue 95P C 401 source : AC3 31) chain C residue 29 type sequence E description binding site for residue 95P C 401 source : AC3 32) chain C residue 30 type sequence L description binding site for residue 95P C 401 source : AC3 33) chain C residue 31 type sequence T description binding site for residue 95P C 401 source : AC3 34) chain C residue 177 type sequence M description binding site for residue 95P C 401 source : AC3 35) chain D residue 17 type sequence V description binding site for residue 95P D 401 source : AC4 36) chain D residue 18 type sequence M description binding site for residue 95P D 401 source : AC4 37) chain D residue 21 type sequence G description binding site for residue 95P D 401 source : AC4 38) chain D residue 22 type sequence R description binding site for residue 95P D 401 source : AC4 39) chain D residue 26 type sequence G description binding site for residue 95P D 401 source : AC4 40) chain D residue 27 type sequence T description binding site for residue 95P D 401 source : AC4 41) chain D residue 28 type sequence G description binding site for residue 95P D 401 source : AC4 42) chain D residue 29 type sequence E description binding site for residue 95P D 401 source : AC4 43) chain D residue 30 type sequence L description binding site for residue 95P D 401 source : AC4 44) chain D residue 31 type sequence T description binding site for residue 95P D 401 source : AC4 45) chain D residue 177 type sequence M description binding site for residue 95P D 401 source : AC4 46) chain E residue 17 type sequence V description binding site for residue 95P E 401 source : AC5 47) chain E residue 18 type sequence M description binding site for residue 95P E 401 source : AC5 48) chain E residue 21 type sequence G description binding site for residue 95P E 401 source : AC5 49) chain E residue 22 type sequence R description binding site for residue 95P E 401 source : AC5 50) chain E residue 26 type sequence G description binding site for residue 95P E 401 source : AC5 51) chain E residue 27 type sequence T description binding site for residue 95P E 401 source : AC5 52) chain E residue 28 type sequence G description binding site for residue 95P E 401 source : AC5 53) chain E residue 29 type sequence E description binding site for residue 95P E 401 source : AC5 54) chain E residue 30 type sequence L description binding site for residue 95P E 401 source : AC5 55) chain E residue 31 type sequence T description binding site for residue 95P E 401 source : AC5 56) chain F residue 18 type sequence M description binding site for residue 95P F 401 source : AC6 57) chain F residue 21 type sequence G description binding site for residue 95P F 401 source : AC6 58) chain F residue 22 type sequence R description binding site for residue 95P F 401 source : AC6 59) chain F residue 26 type sequence G description binding site for residue 95P F 401 source : AC6 60) chain F residue 27 type sequence T description binding site for residue 95P F 401 source : AC6 61) chain F residue 28 type sequence G description binding site for residue 95P F 401 source : AC6 62) chain F residue 29 type sequence E description binding site for residue 95P F 401 source : AC6 63) chain F residue 30 type sequence L description binding site for residue 95P F 401 source : AC6 64) chain F residue 31 type sequence T description binding site for residue 95P F 401 source : AC6 65) chain F residue 177 type sequence M description binding site for residue 95P F 401 source : AC6 66) chain H residue 27 type sequence T description binding site for residue 95P F 401 source : AC6 67) chain G residue 18 type sequence M description binding site for residue 95P G 401 source : AC7 68) chain G residue 21 type sequence G description binding site for residue 95P G 401 source : AC7 69) chain G residue 22 type sequence R description binding site for residue 95P G 401 source : AC7 70) chain G residue 26 type sequence G description binding site for residue 95P G 401 source : AC7 71) chain G residue 27 type sequence T description binding site for residue 95P G 401 source : AC7 72) chain G residue 28 type sequence G description binding site for residue 95P G 401 source : AC7 73) chain G residue 29 type sequence E description binding site for residue 95P G 401 source : AC7 74) chain G residue 30 type sequence L description binding site for residue 95P G 401 source : AC7 75) chain G residue 31 type sequence T description binding site for residue 95P G 401 source : AC7 76) chain H residue 17 type sequence V description binding site for residue 95P H 401 source : AC8 77) chain H residue 18 type sequence M description binding site for residue 95P H 401 source : AC8 78) chain H residue 21 type sequence G description binding site for residue 95P H 401 source : AC8 79) chain H residue 22 type sequence R description binding site for residue 95P H 401 source : AC8 80) chain H residue 24 type sequence A description binding site for residue 95P H 401 source : AC8 81) chain H residue 26 type sequence G description binding site for residue 95P H 401 source : AC8 82) chain H residue 27 type sequence T description binding site for residue 95P H 401 source : AC8 83) chain H residue 28 type sequence G description binding site for residue 95P H 401 source : AC8 84) chain H residue 29 type sequence E description binding site for residue 95P H 401 source : AC8 85) chain H residue 30 type sequence L description binding site for residue 95P H 401 source : AC8 86) chain H residue 31 type sequence T description binding site for residue 95P H 401 source : AC8 87) chain A residue 273-285 type prosite sequence GKLRLLYECNPMA description FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA source prosite : PS00124

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