eF-site ID 5q01-F PDB Code 5q01 Chain F click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence F:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain F residue 20 type sequence E description binding site for residue 95G F 401 source : AC6 2) chain F residue 21 type sequence G description binding site for residue 95G F 401 source : AC6 3) chain F residue 22 type sequence R description binding site for residue 95G F 401 source : AC6 4) chain F residue 26 type sequence G description binding site for residue 95G F 401 source : AC6 5) chain F residue 28 type sequence G description binding site for residue 95G F 401 source : AC6 6) chain F residue 29 type sequence E description binding site for residue 95G F 401 source : AC6 7) chain F residue 30 type sequence L description binding site for residue 95G F 401 source : AC6 8) chain F residue 31 type sequence T description binding site for residue 95G F 401 source : AC6 9) chain F residue 161 type sequence A description binding site for residue 95G F 401 source : AC6 10) chain F residue 175 type sequence L description binding site for residue 95G F 401 source : AC6 11) chain F residue 177 type sequence M description binding site for residue 95G F 401 source : AC6 12) chain F residue 27 type sequence T description binding site for residue 95G H 401 source : AC8 13) chain F residue 28 type sequence G description binding site for residue 95G H 401 source : AC8

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