eF-site ID 5q01-E PDB Code 5q01 Chain E click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence E:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain E residue 21 type sequence G description binding site for residue 95G E 401 source : AC5 2) chain E residue 24 type sequence A description binding site for residue 95G E 401 source : AC5 3) chain E residue 26 type sequence G description binding site for residue 95G E 401 source : AC5 4) chain E residue 27 type sequence T description binding site for residue 95G E 401 source : AC5 5) chain E residue 28 type sequence G description binding site for residue 95G E 401 source : AC5 6) chain E residue 29 type sequence E description binding site for residue 95G E 401 source : AC5 7) chain E residue 30 type sequence L description binding site for residue 95G E 401 source : AC5 8) chain E residue 31 type sequence T description binding site for residue 95G E 401 source : AC5 9) chain E residue 34 type sequence L description binding site for residue 95G E 401 source : AC5 10) chain E residue 161 type sequence A description binding site for residue 95G E 401 source : AC5 11) chain E residue 175 type sequence L description binding site for residue 95G E 401 source : AC5 12) chain E residue 177 type sequence M description binding site for residue 95G E 401 source : AC5 13) chain E residue 27 type sequence T description binding site for residue 95G G 401 source : AC7

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