eF-site ID 5q01-ABCDEFGH
PDB Code 5q01
Chain A, B, C, D, E, F, G, H

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Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS
EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF
GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA
MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA
KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL
VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT
TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
C:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
E:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS
EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF
GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA
MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA
KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL
VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT
TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
F:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
G:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
H:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description


Functional site

1) chain A
residue 18
type
sequence M
description binding site for residue 95G A 401
source : AC1

2) chain A
residue 21
type
sequence G
description binding site for residue 95G A 401
source : AC1

3) chain A
residue 22
type
sequence R
description binding site for residue 95G A 401
source : AC1

4) chain A
residue 26
type
sequence G
description binding site for residue 95G A 401
source : AC1

5) chain A
residue 27
type
sequence T
description binding site for residue 95G A 401
source : AC1

6) chain A
residue 28
type
sequence G
description binding site for residue 95G A 401
source : AC1

7) chain A
residue 29
type
sequence E
description binding site for residue 95G A 401
source : AC1

8) chain A
residue 30
type
sequence L
description binding site for residue 95G A 401
source : AC1

9) chain A
residue 31
type
sequence T
description binding site for residue 95G A 401
source : AC1

10) chain A
residue 175
type
sequence L
description binding site for residue 95G A 401
source : AC1

11) chain A
residue 177
type
sequence M
description binding site for residue 95G A 401
source : AC1

12) chain C
residue 27
type
sequence T
description binding site for residue 95G A 401
source : AC1

13) chain B
residue 20
type
sequence E
description binding site for residue 95G B 401
source : AC2

14) chain B
residue 21
type
sequence G
description binding site for residue 95G B 401
source : AC2

15) chain B
residue 22
type
sequence R
description binding site for residue 95G B 401
source : AC2

16) chain B
residue 26
type
sequence G
description binding site for residue 95G B 401
source : AC2

17) chain B
residue 27
type
sequence T
description binding site for residue 95G B 401
source : AC2

18) chain B
residue 28
type
sequence G
description binding site for residue 95G B 401
source : AC2

19) chain B
residue 29
type
sequence E
description binding site for residue 95G B 401
source : AC2

20) chain B
residue 30
type
sequence L
description binding site for residue 95G B 401
source : AC2

21) chain B
residue 31
type
sequence T
description binding site for residue 95G B 401
source : AC2

22) chain B
residue 161
type
sequence A
description binding site for residue 95G B 401
source : AC2

23) chain B
residue 175
type
sequence L
description binding site for residue 95G B 401
source : AC2

24) chain B
residue 177
type
sequence M
description binding site for residue 95G B 401
source : AC2

25) chain D
residue 27
type
sequence T
description binding site for residue 95G B 401
source : AC2

26) chain C
residue 17
type
sequence V
description binding site for residue 95G C 401
source : AC3

27) chain C
residue 20
type
sequence E
description binding site for residue 95G C 401
source : AC3

28) chain C
residue 21
type
sequence G
description binding site for residue 95G C 401
source : AC3

29) chain C
residue 26
type
sequence G
description binding site for residue 95G C 401
source : AC3

30) chain C
residue 27
type
sequence T
description binding site for residue 95G C 401
source : AC3

31) chain C
residue 28
type
sequence G
description binding site for residue 95G C 401
source : AC3

32) chain C
residue 29
type
sequence E
description binding site for residue 95G C 401
source : AC3

33) chain C
residue 30
type
sequence L
description binding site for residue 95G C 401
source : AC3

34) chain C
residue 31
type
sequence T
description binding site for residue 95G C 401
source : AC3

35) chain C
residue 175
type
sequence L
description binding site for residue 95G C 401
source : AC3

36) chain C
residue 177
type
sequence M
description binding site for residue 95G C 401
source : AC3

37) chain D
residue 20
type
sequence E
description binding site for residue 95G D 401
source : AC4

38) chain D
residue 21
type
sequence G
description binding site for residue 95G D 401
source : AC4

39) chain D
residue 26
type
sequence G
description binding site for residue 95G D 401
source : AC4

40) chain D
residue 28
type
sequence G
description binding site for residue 95G D 401
source : AC4

41) chain D
residue 30
type
sequence L
description binding site for residue 95G D 401
source : AC4

42) chain D
residue 31
type
sequence T
description binding site for residue 95G D 401
source : AC4

43) chain D
residue 161
type
sequence A
description binding site for residue 95G D 401
source : AC4

44) chain D
residue 175
type
sequence L
description binding site for residue 95G D 401
source : AC4

45) chain D
residue 177
type
sequence M
description binding site for residue 95G D 401
source : AC4

46) chain E
residue 21
type
sequence G
description binding site for residue 95G E 401
source : AC5

47) chain E
residue 24
type
sequence A
description binding site for residue 95G E 401
source : AC5

48) chain E
residue 26
type
sequence G
description binding site for residue 95G E 401
source : AC5

49) chain E
residue 27
type
sequence T
description binding site for residue 95G E 401
source : AC5

50) chain E
residue 28
type
sequence G
description binding site for residue 95G E 401
source : AC5

51) chain E
residue 29
type
sequence E
description binding site for residue 95G E 401
source : AC5

52) chain E
residue 30
type
sequence L
description binding site for residue 95G E 401
source : AC5

53) chain E
residue 31
type
sequence T
description binding site for residue 95G E 401
source : AC5

54) chain E
residue 34
type
sequence L
description binding site for residue 95G E 401
source : AC5

55) chain E
residue 161
type
sequence A
description binding site for residue 95G E 401
source : AC5

56) chain E
residue 175
type
sequence L
description binding site for residue 95G E 401
source : AC5

57) chain E
residue 177
type
sequence M
description binding site for residue 95G E 401
source : AC5

58) chain F
residue 20
type
sequence E
description binding site for residue 95G F 401
source : AC6

59) chain F
residue 21
type
sequence G
description binding site for residue 95G F 401
source : AC6

60) chain F
residue 22
type
sequence R
description binding site for residue 95G F 401
source : AC6

61) chain F
residue 26
type
sequence G
description binding site for residue 95G F 401
source : AC6

62) chain F
residue 28
type
sequence G
description binding site for residue 95G F 401
source : AC6

63) chain F
residue 29
type
sequence E
description binding site for residue 95G F 401
source : AC6

64) chain F
residue 30
type
sequence L
description binding site for residue 95G F 401
source : AC6

65) chain F
residue 31
type
sequence T
description binding site for residue 95G F 401
source : AC6

66) chain F
residue 161
type
sequence A
description binding site for residue 95G F 401
source : AC6

67) chain F
residue 175
type
sequence L
description binding site for residue 95G F 401
source : AC6

68) chain F
residue 177
type
sequence M
description binding site for residue 95G F 401
source : AC6

69) chain H
residue 27
type
sequence T
description binding site for residue 95G F 401
source : AC6

70) chain H
residue 28
type
sequence G
description binding site for residue 95G F 401
source : AC6

71) chain E
residue 27
type
sequence T
description binding site for residue 95G G 401
source : AC7

72) chain G
residue 21
type
sequence G
description binding site for residue 95G G 401
source : AC7

73) chain G
residue 22
type
sequence R
description binding site for residue 95G G 401
source : AC7

74) chain G
residue 26
type
sequence G
description binding site for residue 95G G 401
source : AC7

75) chain G
residue 27
type
sequence T
description binding site for residue 95G G 401
source : AC7

76) chain G
residue 28
type
sequence G
description binding site for residue 95G G 401
source : AC7

77) chain G
residue 29
type
sequence E
description binding site for residue 95G G 401
source : AC7

78) chain G
residue 30
type
sequence L
description binding site for residue 95G G 401
source : AC7

79) chain G
residue 31
type
sequence T
description binding site for residue 95G G 401
source : AC7

80) chain G
residue 34
type
sequence L
description binding site for residue 95G G 401
source : AC7

81) chain G
residue 175
type
sequence L
description binding site for residue 95G G 401
source : AC7

82) chain G
residue 177
type
sequence M
description binding site for residue 95G G 401
source : AC7

83) chain F
residue 27
type
sequence T
description binding site for residue 95G H 401
source : AC8

84) chain F
residue 28
type
sequence G
description binding site for residue 95G H 401
source : AC8

85) chain H
residue 17
type
sequence V
description binding site for residue 95G H 401
source : AC8

86) chain H
residue 20
type
sequence E
description binding site for residue 95G H 401
source : AC8

87) chain H
residue 21
type
sequence G
description binding site for residue 95G H 401
source : AC8

88) chain H
residue 22
type
sequence R
description binding site for residue 95G H 401
source : AC8

89) chain H
residue 26
type
sequence G
description binding site for residue 95G H 401
source : AC8

90) chain H
residue 27
type
sequence T
description binding site for residue 95G H 401
source : AC8

91) chain H
residue 28
type
sequence G
description binding site for residue 95G H 401
source : AC8

92) chain H
residue 29
type
sequence E
description binding site for residue 95G H 401
source : AC8

93) chain H
residue 30
type
sequence L
description binding site for residue 95G H 401
source : AC8

94) chain H
residue 31
type
sequence T
description binding site for residue 95G H 401
source : AC8

95) chain H
residue 161
type
sequence A
description binding site for residue 95G H 401
source : AC8

96) chain H
residue 175
type
sequence L
description binding site for residue 95G H 401
source : AC8

97) chain H
residue 177
type
sequence M
description binding site for residue 95G H 401
source : AC8

98) chain A
residue 273-285
type prosite
sequence GKLRLLYECNPMA
description FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
source prosite : PS00124


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