eF-site ID 5q01-A PDB Code 5q01 Chain A click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain A residue 18 type sequence M description binding site for residue 95G A 401 source : AC1 2) chain A residue 21 type sequence G description binding site for residue 95G A 401 source : AC1 3) chain A residue 22 type sequence R description binding site for residue 95G A 401 source : AC1 4) chain A residue 26 type sequence G description binding site for residue 95G A 401 source : AC1 5) chain A residue 27 type sequence T description binding site for residue 95G A 401 source : AC1 6) chain A residue 28 type sequence G description binding site for residue 95G A 401 source : AC1 7) chain A residue 29 type sequence E description binding site for residue 95G A 401 source : AC1 8) chain A residue 30 type sequence L description binding site for residue 95G A 401 source : AC1 9) chain A residue 31 type sequence T description binding site for residue 95G A 401 source : AC1 10) chain A residue 175 type sequence L description binding site for residue 95G A 401 source : AC1 11) chain A residue 177 type sequence M description binding site for residue 95G A 401 source : AC1 12) chain A residue 273-285 type prosite sequence GKLRLLYECNPMA description FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA source prosite : PS00124

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