eF-site ID 5pzz-A
PDB Code 5pzz
Chain A

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Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea
Classification HYDROLASE/HYDROLASE inhibitor
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGVKKLDVLSNDLVMNMLKSSFATCVLVS
EEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIF
GIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLA
MDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYA
KDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTL
VYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMAT
TGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description (1)  Fructose-1,6-bisphosphatase 1


Functional site

1) chain A
residue 17
type
ligand
sequence V
description binding site for residue 94Y A 401
source : AC1

2) chain A
residue 21
type
ligand
sequence G
description binding site for residue 94Y A 401
source : AC1

3) chain A
residue 22
type
ligand
sequence R
description binding site for residue 94Y A 401
source : AC1

4) chain A
residue 24
type
ligand
sequence A
description binding site for residue 94Y A 401
source : AC1

5) chain A
residue 26
type
ligand
sequence G
description binding site for residue 94Y A 401
source : AC1

6) chain A
residue 27
type
ligand
sequence T
description binding site for residue 94Y A 401
source : AC1

7) chain A
residue 28
type
ligand
sequence G
description binding site for residue 94Y A 401
source : AC1

8) chain A
residue 29
type
ligand
sequence E
description binding site for residue 94Y A 401
source : AC1

9) chain A
residue 30
type
ligand
sequence L
description binding site for residue 94Y A 401
source : AC1

10) chain A
residue 31
type
ligand
sequence T
description binding site for residue 94Y A 401
source : AC1

11) chain A
residue 17-18
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence VM
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

12) chain A
residue 20-22
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence EGR
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

13) chain A
residue 24-31
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence ARGTGELT
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

14) chain A
residue 34
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence L
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

15) chain A
residue 113
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence Y
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

16) chain A
residue 177
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence M
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

17) chain A
residue 179
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence C
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_A_401

18) chain A
residue 27-28
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence TG
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_C_401

19) chain A
residue 31-32
type binding
ligand 94Y: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide
sequence TQ
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide binding site
source pdb_hetatom : 94Y_5pzz_C_401


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