eF-site ID 5pzv-B PDB Code 5pzv Chain B click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromopyridin-2-yl)-3-(4-chlorophenyl)sulfonylurea Classification HYDROLASE/HYDROLASE inhibitor Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description (1)  Fructose-1,6-bisphosphatase 1 Functional site 1) chain B residue 18 type ligand sequence M description binding site for residue 94G B 401 source : AC2 2) chain B residue 20 type ligand sequence E description binding site for residue 94G B 401 source : AC2 3) chain B residue 21 type ligand sequence G description binding site for residue 94G B 401 source : AC2 4) chain B residue 22 type ligand sequence R description binding site for residue 94G B 401 source : AC2 5) chain B residue 26 type ligand sequence G description binding site for residue 94G B 401 source : AC2 6) chain B residue 27 type ligand sequence T description binding site for residue 94G B 401 source : AC2 7) chain B residue 28 type ligand sequence G description binding site for residue 94G B 401 source : AC2 8) chain B residue 29 type ligand sequence E description binding site for residue 94G B 401 source : AC2 9) chain B residue 30 type ligand sequence L description binding site for residue 94G B 401 source : AC2 10) chain B residue 31 type ligand sequence T description binding site for residue 94G B 401 source : AC2 11) chain B residue 27 type ligand sequence T description binding site for residue 94G D 401 source : AC4 12) chain B residue 28 type ligand sequence G description binding site for residue 94G D 401 source : AC4 13) chain B residue 17-18 type binding ligand 94G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide sequence VM description N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site source pdb_hetatom : 94G_5pzv_B_401 14) chain B residue 20-22 type binding ligand 94G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide sequence EGR description N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site source pdb_hetatom : 94G_5pzv_B_401 15) chain B residue 24-31 type binding ligand 94G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide sequence ARGTGELT description N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site source pdb_hetatom : 94G_5pzv_B_401 16) chain B residue 113 type binding ligand 94G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide sequence Y description N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site source pdb_hetatom : 94G_5pzv_B_401 17) chain B residue 177 type binding ligand 94G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide sequence M description N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site source pdb_hetatom : 94G_5pzv_B_401 18) chain B residue 26-28 type binding ligand 94G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide sequence GTG description N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site source pdb_hetatom : 94G_5pzv_D_401

Display surface Download Links