eF-site ID 5pzu-D
PDB Code 5pzu
Chain D

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Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor [5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description


Functional site

1) chain D
residue 17
type
sequence V
description binding site for residue 94D D 401
source : AC4

2) chain D
residue 20
type
sequence E
description binding site for residue 94D D 401
source : AC4

3) chain D
residue 21
type
sequence G
description binding site for residue 94D D 401
source : AC4

4) chain D
residue 26
type
sequence G
description binding site for residue 94D D 401
source : AC4

5) chain D
residue 27
type
sequence T
description binding site for residue 94D D 401
source : AC4

6) chain D
residue 28
type
sequence G
description binding site for residue 94D D 401
source : AC4

7) chain D
residue 29
type
sequence E
description binding site for residue 94D D 401
source : AC4

8) chain D
residue 30
type
sequence L
description binding site for residue 94D D 401
source : AC4

9) chain D
residue 31
type
sequence T
description binding site for residue 94D D 401
source : AC4

10) chain D
residue 112
type
sequence K
description binding site for residue 94D D 401
source : AC4

11) chain D
residue 113
type
sequence Y
description binding site for residue 94D D 401
source : AC4

12) chain D
residue 140
type
sequence R
description binding site for residue 94D D 401
source : AC4


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