eF-site ID 5pzt-H PDB Code 5pzt Chain H click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3-ethyl-4-phenylphenyl)sulfonylurea Classification HYDROLASE/HYDROLASE INHIBITOR Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence H:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIV EPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTD EPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFM LDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKDFDPAVTE YIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYP ANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDV IPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description (1)  Fructose-1,6-bisphosphatase 1 Functional site 1) chain H residue 17 type ligand sequence V description binding site for residue 947 H 401 source : AC8 2) chain H residue 20 type ligand sequence E description binding site for residue 947 H 401 source : AC8 3) chain H residue 21 type ligand sequence G description binding site for residue 947 H 401 source : AC8 4) chain H residue 22 type ligand sequence R description binding site for residue 947 H 401 source : AC8 5) chain H residue 26 type ligand sequence G description binding site for residue 947 H 401 source : AC8 6) chain H residue 27 type ligand sequence T description binding site for residue 947 H 401 source : AC8 7) chain H residue 28 type ligand sequence G description binding site for residue 947 H 401 source : AC8 8) chain H residue 29 type ligand sequence E description binding site for residue 947 H 401 source : AC8 9) chain H residue 30 type ligand sequence L description binding site for residue 947 H 401 source : AC8 10) chain H residue 31 type ligand sequence T description binding site for residue 947 H 401 source : AC8 11) chain H residue 27-28 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence TG description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_F_401 12) chain H residue 31-32 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence TQ description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_F_401 13) chain H residue 16-18 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence FVM description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_H_401 14) chain H residue 20-22 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence EGR description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_H_401 15) chain H residue 24-31 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence ARGTGELT description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_H_401 16) chain H residue 34 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence L description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_H_401 17) chain H residue 113 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence Y description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_H_401 18) chain H residue 177-179 type binding ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide sequence MDC description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site source pdb_hetatom : 947_5pzt_H_401

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