eF-site ID 5pzt-E
PDB Code 5pzt
Chain E

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Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3-ethyl-4-phenylphenyl)sulfonylurea
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence E:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAI
IVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKS
TDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNC
FMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKDFDPAV
TEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFL
YPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVL
DVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description (1)  Fructose-1,6-bisphosphatase 1


Functional site

1) chain E
residue 17
type
ligand
sequence V
description binding site for residue 947 E 401
source : AC5

2) chain E
residue 20
type
ligand
sequence E
description binding site for residue 947 E 401
source : AC5

3) chain E
residue 21
type
ligand
sequence G
description binding site for residue 947 E 401
source : AC5

4) chain E
residue 22
type
ligand
sequence R
description binding site for residue 947 E 401
source : AC5

5) chain E
residue 26
type
ligand
sequence G
description binding site for residue 947 E 401
source : AC5

6) chain E
residue 28
type
ligand
sequence G
description binding site for residue 947 E 401
source : AC5

7) chain E
residue 29
type
ligand
sequence E
description binding site for residue 947 E 401
source : AC5

8) chain E
residue 30
type
ligand
sequence L
description binding site for residue 947 E 401
source : AC5

9) chain E
residue 31
type
ligand
sequence T
description binding site for residue 947 E 401
source : AC5

10) chain E
residue 179
type
ligand
sequence C
description binding site for residue 947 E 401
source : AC5

11) chain E
residue 17-18
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence VM
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_E_401

12) chain E
residue 20-22
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence EGR
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_E_401

13) chain E
residue 24-32
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence ARGTGELTQ
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_E_401

14) chain E
residue 34
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence L
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_E_401

15) chain E
residue 113
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence Y
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_E_401

16) chain E
residue 177-179
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence MDC
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_E_401

17) chain E
residue 27-28
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence TG
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_G_401

18) chain E
residue 31-32
type binding
ligand 947: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide
sequence TQ
description N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-2-ethyl[1,1'-biphenyl]-4-sulfonamide binding site
source pdb_hetatom : 947_5pzt_G_401


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