eF-site ID 5pzs-D
PDB Code 5pzs
Chain D

click to enlarge
Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[6-[(3-chlorophenyl)sulfonylcarbamoylamino]hexyl]urea
Classification HYDROLASE/HYDROLASE inhibitor
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence D:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description (1)  Fructose-1,6-bisphosphatase 1


Functional site

1) chain D
residue 17
type
ligand
sequence V
description binding site for residue 93Y B 401
source : AC2

2) chain D
residue 21
type
ligand
sequence G
description binding site for residue 93Y B 401
source : AC2

3) chain D
residue 22
type
ligand
sequence R
description binding site for residue 93Y B 401
source : AC2

4) chain D
residue 26
type
ligand
sequence G
description binding site for residue 93Y B 401
source : AC2

5) chain D
residue 27
type
ligand
sequence T
description binding site for residue 93Y B 401
source : AC2

6) chain D
residue 28
type
ligand
sequence G
description binding site for residue 93Y B 401
source : AC2

7) chain D
residue 29
type
ligand
sequence E
description binding site for residue 93Y B 401
source : AC2

8) chain D
residue 30
type
ligand
sequence L
description binding site for residue 93Y B 401
source : AC2

9) chain D
residue 31
type
ligand
sequence T
description binding site for residue 93Y B 401
source : AC2

10) chain D
residue 177
type
ligand
sequence M
description binding site for residue 93Y B 401
source : AC2

11) chain D
residue 17-18
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence VM
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401

12) chain D
residue 20-22
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence EGR
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401

13) chain D
residue 24
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence A
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401

14) chain D
residue 26-32
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence GTGELTQ
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401

15) chain D
residue 34
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence L
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401

16) chain D
residue 113
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence Y
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401

17) chain D
residue 177
type binding
ligand 93Y: N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
sequence M
description N,N'-(hexane-1,6-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
source pdb_hetatom : 93Y_5pzs_B_401


Display surface

Download
Links