eF-site ID 5pzs-B
PDB Code 5pzs
Chain B

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Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[6-[(3-chlorophenyl)sulfonylcarbamoylamino]hexyl]urea
Classification HYDROLASE/HYDROLASE inhibitor
Compound Fructose-1,6-bisphosphatase 1
Source (Q2TU34_HUMAN)
Sequence B:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV
RKAGIAHLYGIAGKLDVLSNDLVMNMLKSSFATCVLVSEE
DKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGI
YRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMD
CGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKD
FDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVY
GGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTG
KEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS
Description


Functional site

1) chain B
residue 17
type
sequence V
description binding site for residue 93Y B 401
source : AC2

2) chain B
residue 18
type
sequence M
description binding site for residue 93Y B 401
source : AC2

3) chain B
residue 21
type
sequence G
description binding site for residue 93Y B 401
source : AC2

4) chain B
residue 24
type
sequence A
description binding site for residue 93Y B 401
source : AC2

5) chain B
residue 26
type
sequence G
description binding site for residue 93Y B 401
source : AC2

6) chain B
residue 27
type
sequence T
description binding site for residue 93Y B 401
source : AC2

7) chain B
residue 28
type
sequence G
description binding site for residue 93Y B 401
source : AC2

8) chain B
residue 29
type
sequence E
description binding site for residue 93Y B 401
source : AC2

9) chain B
residue 30
type
sequence L
description binding site for residue 93Y B 401
source : AC2

10) chain B
residue 31
type
sequence T
description binding site for residue 93Y B 401
source : AC2


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