eF-site ID 5pzq-A PDB Code 5pzq Chain A click to enlarge Title Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid Classification HYDROLASE/HYDROLASE inhibitor Compound Fructose-1,6-bisphosphatase 1 Source (Q2TU34_HUMAN) Sequence A:  DVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAV RKAGIAHLYGIAGKKLDVLSNDLVMNMLKSSFATCVLVSE EDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFG IYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAM DCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAK DFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLV YGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATT GKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHS Description Functional site 1) chain A residue 17 type sequence V description binding site for residue 93V A 401 source : AC1 2) chain A residue 20 type sequence E description binding site for residue 93V A 401 source : AC1 3) chain A residue 21 type sequence G description binding site for residue 93V A 401 source : AC1 4) chain A residue 24 type sequence A description binding site for residue 93V A 401 source : AC1 5) chain A residue 26 type sequence G description binding site for residue 93V A 401 source : AC1 6) chain A residue 27 type sequence T description binding site for residue 93V A 401 source : AC1 7) chain A residue 28 type sequence G description binding site for residue 93V A 401 source : AC1 8) chain A residue 29 type sequence E description binding site for residue 93V A 401 source : AC1 9) chain A residue 30 type sequence L description binding site for residue 93V A 401 source : AC1 10) chain A residue 34 type sequence L description binding site for residue 93V A 401 source : AC1 11) chain A residue 112 type sequence K description binding site for residue 93V A 401 source : AC1 12) chain A residue 113 type sequence Y description binding site for residue 93V A 401 source : AC1 13) chain A residue 140 type sequence R description binding site for residue 93V A 401 source : AC1 14) chain A residue 25 type sequence R description binding site for residue 93V B 401 source : AC2 15) chain A residue 273-285 type prosite sequence GKLRLLYECNPMA description FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA source prosite : PS00124

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