eF-site ID 5owt-A PDB Code 5owt Chain A click to enlarge Title Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione Classification TRANSFERASE Compound Tankyrase-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS APGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIM RPE Description Functional site 1) chain A residue 977 type sequence R description binding site for residue SO4 A 1201 source : AC1 2) chain A residue 979 type sequence H description binding site for residue SO4 A 1201 source : AC1 3) chain A residue 980 type sequence R description binding site for residue SO4 A 1201 source : AC1 4) chain A residue 1067 type sequence K description binding site for residue SO4 A 1201 source : AC1 5) chain A residue 1070 type sequence Q description binding site for residue SO4 A 1201 source : AC1 6) chain A residue 1132 type sequence N description binding site for residue SO4 A 1201 source : AC1 7) chain A residue 990 type sequence N description binding site for residue SO4 A 1202 source : AC2 8) chain A residue 991 type sequence R description binding site for residue SO4 A 1202 source : AC2 9) chain A residue 1160 type sequence P description binding site for residue SO4 A 1202 source : AC2 10) chain A residue 1161 type sequence E description binding site for residue SO4 A 1202 source : AC2 11) chain A residue 1031 type sequence H description binding site for residue F37 A 1203 source : AC3 12) chain A residue 1032 type sequence G description binding site for residue F37 A 1203 source : AC3 13) chain A residue 1034 type sequence P description binding site for residue F37 A 1203 source : AC3 14) chain A residue 1035 type sequence F description binding site for residue F37 A 1203 source : AC3 15) chain A residue 1047 type sequence R description binding site for residue F37 A 1203 source : AC3 16) chain A residue 1048 type sequence H description binding site for residue F37 A 1203 source : AC3 17) chain A residue 1049 type sequence A description binding site for residue F37 A 1203 source : AC3 18) chain A residue 1050 type sequence Y description binding site for residue F37 A 1203 source : AC3 19) chain A residue 1060 type sequence Y description binding site for residue F37 A 1203 source : AC3 20) chain A residue 1067 type sequence K description binding site for residue F37 A 1203 source : AC3 21) chain A residue 1068 type sequence S description binding site for residue F37 A 1203 source : AC3 22) chain A residue 1071 type sequence Y description binding site for residue F37 A 1203 source : AC3 23) chain A residue 1138 type sequence E description binding site for residue F37 A 1203 source : AC3 24) chain A residue 1081 type sequence C description binding site for residue ZN A 1204 source : AC4 25) chain A residue 1084 type sequence H description binding site for residue ZN A 1204 source : AC4 26) chain A residue 1089 type sequence C description binding site for residue ZN A 1204 source : AC4 27) chain A residue 1092 type sequence C description binding site for residue ZN A 1204 source : AC4 28) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links