eF-site ID 5ofa-B PDB Code 5ofa Chain B click to enlarge Title Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R Classification NUCLEAR PROTEIN Compound MORC family CW-type zinc finger protein 2 Source (MORC2_HUMAN) Sequence B:  NYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDAD ATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQF GKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDT MTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEK FAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNL KLMDNGEPELDIISNPRDIQMAEEGTKPERRSFRAYAAVL YIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTR AEQEVKKAEHVARIAEEKAREAESKARTLEVRLLTRDSRV MLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNFVF GVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGV VGVVDVPYLVLEPRHNKQDFADAKEYRHLLRAMGEHLAQY WKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRA MEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPD PEQDRCEASEQKQKVPLGTF Description (1)  MORC family CW-type zinc finger protein 2 Functional site 1) chain B residue 499 type sequence C description binding site for residue ZN B 701 source : AC1 2) chain B residue 502 type sequence C description binding site for residue ZN B 701 source : AC1 3) chain B residue 525 type sequence C description binding site for residue ZN B 701 source : AC1 4) chain B residue 536 type sequence C description binding site for residue ZN B 701 source : AC1 5) chain B residue 35 type sequence E description binding site for residue ANP B 702 source : AC2 6) chain B residue 39 type sequence N description binding site for residue ANP B 702 source : AC2 7) chain B residue 43 type sequence A description binding site for residue ANP B 702 source : AC2 8) chain B residue 68 type sequence D description binding site for residue ANP B 702 source : AC2 9) chain B residue 73 type sequence M description binding site for residue ANP B 702 source : AC2 10) chain B residue 81 type sequence V description binding site for residue ANP B 702 source : AC2 11) chain B residue 87 type sequence S description binding site for residue ANP B 702 source : AC2 12) chain B residue 89 type sequence K description binding site for residue ANP B 702 source : AC2 13) chain B residue 98 type sequence G description binding site for residue ANP B 702 source : AC2 14) chain B residue 99 type sequence Q description binding site for residue ANP B 702 source : AC2 15) chain B residue 100 type sequence Y description binding site for residue ANP B 702 source : AC2 16) chain B residue 101 type sequence G description binding site for residue ANP B 702 source : AC2 17) chain B residue 102 type sequence N description binding site for residue ANP B 702 source : AC2 18) chain B residue 103 type sequence G description binding site for residue ANP B 702 source : AC2 19) chain B residue 104 type sequence L description binding site for residue ANP B 702 source : AC2 20) chain B residue 105 type sequence K description binding site for residue ANP B 702 source : AC2 21) chain B residue 197 type sequence T description binding site for residue ANP B 702 source : AC2 22) chain B residue 427 type sequence K description binding site for residue ANP B 702 source : AC2 23) chain B residue 39 type sequence N description binding site for residue MG B 703 source : AC3 24) chain B residue 490-544 type ZN_FING sequence AMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNP DPEQDRCEASEQKQK description CW-type => ECO:0000255|PROSITE-ProRule:PRU00454, ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 39 type BINDING sequence N description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 87 type BINDING sequence S description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 99 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 427 type BINDING sequence K description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 499 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 502 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 525 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 536 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links