eF-site ID 5ofa-AB PDB Code 5ofa Chain A, B click to enlarge Title Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R Classification NUCLEAR PROTEIN Compound MORC family CW-type zinc finger protein 2 Source (MORC2_HUMAN) Sequence A:  TNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDA DATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQ FGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKED TMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVE KFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFN LKLMDNGEPELDIISNPRDIQMAETKPERRSFRAYAAVLY IDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRA EQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDS RVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNF VFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACG GVVGVVDVPYLVLEPRHNKQDFADAKEYRHLLRAMGEHLA QYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRR RAMEIPTTIQCDLCLKWRTLPDTWVCSMNPDPEQDRCEAS EQKQKVPLGTF B:  NYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDAD ATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQF GKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDT MTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEK FAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNL KLMDNGEPELDIISNPRDIQMAEEGTKPERRSFRAYAAVL YIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTR AEQEVKKAEHVARIAEEKAREAESKARTLEVRLLTRDSRV MLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNFVF GVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGV VGVVDVPYLVLEPRHNKQDFADAKEYRHLLRAMGEHLAQY WKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRRRA MEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPD PEQDRCEASEQKQKVPLGTF Description (1)  MORC family CW-type zinc finger protein 2 Functional site 1) chain B residue 499 type sequence C description binding site for residue ZN B 701 source : AC1 2) chain B residue 502 type sequence C description binding site for residue ZN B 701 source : AC1 3) chain B residue 525 type sequence C description binding site for residue ZN B 701 source : AC1 4) chain B residue 536 type sequence C description binding site for residue ZN B 701 source : AC1 5) chain B residue 35 type sequence E description binding site for residue ANP B 702 source : AC2 6) chain B residue 39 type sequence N description binding site for residue ANP B 702 source : AC2 7) chain B residue 43 type sequence A description binding site for residue ANP B 702 source : AC2 8) chain B residue 68 type sequence D description binding site for residue ANP B 702 source : AC2 9) chain B residue 73 type sequence M description binding site for residue ANP B 702 source : AC2 10) chain B residue 81 type sequence V description binding site for residue ANP B 702 source : AC2 11) chain B residue 87 type sequence S description binding site for residue ANP B 702 source : AC2 12) chain B residue 89 type sequence K description binding site for residue ANP B 702 source : AC2 13) chain B residue 98 type sequence G description binding site for residue ANP B 702 source : AC2 14) chain B residue 99 type sequence Q description binding site for residue ANP B 702 source : AC2 15) chain B residue 100 type sequence Y description binding site for residue ANP B 702 source : AC2 16) chain B residue 101 type sequence G description binding site for residue ANP B 702 source : AC2 17) chain B residue 102 type sequence N description binding site for residue ANP B 702 source : AC2 18) chain B residue 103 type sequence G description binding site for residue ANP B 702 source : AC2 19) chain B residue 104 type sequence L description binding site for residue ANP B 702 source : AC2 20) chain B residue 105 type sequence K description binding site for residue ANP B 702 source : AC2 21) chain B residue 197 type sequence T description binding site for residue ANP B 702 source : AC2 22) chain B residue 427 type sequence K description binding site for residue ANP B 702 source : AC2 23) chain B residue 39 type sequence N description binding site for residue MG B 703 source : AC3 24) chain A residue 499 type sequence C description binding site for residue ZN A 701 source : AC4 25) chain A residue 502 type sequence C description binding site for residue ZN A 701 source : AC4 26) chain A residue 525 type sequence C description binding site for residue ZN A 701 source : AC4 27) chain A residue 536 type sequence C description binding site for residue ZN A 701 source : AC4 28) chain A residue 35 type sequence E description binding site for residue ANP A 702 source : AC5 29) chain A residue 39 type sequence N description binding site for residue ANP A 702 source : AC5 30) chain A residue 43 type sequence A description binding site for residue ANP A 702 source : AC5 31) chain A residue 68 type sequence D description binding site for residue ANP A 702 source : AC5 32) chain A residue 73 type sequence M description binding site for residue ANP A 702 source : AC5 33) chain A residue 81 type sequence V description binding site for residue ANP A 702 source : AC5 34) chain A residue 87 type sequence S description binding site for residue ANP A 702 source : AC5 35) chain A residue 89 type sequence K description binding site for residue ANP A 702 source : AC5 36) chain A residue 98 type sequence G description binding site for residue ANP A 702 source : AC5 37) chain A residue 99 type sequence Q description binding site for residue ANP A 702 source : AC5 38) chain A residue 100 type sequence Y description binding site for residue ANP A 702 source : AC5 39) chain A residue 101 type sequence G description binding site for residue ANP A 702 source : AC5 40) chain A residue 102 type sequence N description binding site for residue ANP A 702 source : AC5 41) chain A residue 103 type sequence G description binding site for residue ANP A 702 source : AC5 42) chain A residue 104 type sequence L description binding site for residue ANP A 702 source : AC5 43) chain A residue 105 type sequence K description binding site for residue ANP A 702 source : AC5 44) chain A residue 197 type sequence T description binding site for residue ANP A 702 source : AC5 45) chain A residue 427 type sequence K description binding site for residue ANP A 702 source : AC5 46) chain A residue 39 type sequence N description binding site for residue MG A 703 source : AC6 47) chain B residue 490-544 type ZN_FING sequence AMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNP DPEQDRCEASEQKQK description CW-type => ECO:0000255|PROSITE-ProRule:PRU00454, ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 490-544 type ZN_FING sequence AMEIPTTIQCDLCLKWRTLPDTWVCSMNPDPEQDRCEASE QKQK description CW-type => ECO:0000255|PROSITE-ProRule:PRU00454, ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 39 type BINDING sequence N description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 87 type BINDING sequence S description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 99 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 427 type BINDING sequence K description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 39 type BINDING sequence N description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 87 type BINDING sequence S description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 99 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 427 type BINDING sequence K description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 499 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 58) chain B residue 502 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 59) chain B residue 525 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 60) chain B residue 536 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 61) chain A residue 499 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 502 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 63) chain A residue 525 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 64) chain A residue 536 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3

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