eF-site ID 5ofa-A PDB Code 5ofa Chain A click to enlarge Title Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R Classification NUCLEAR PROTEIN Compound MORC family CW-type zinc finger protein 2 Source (MORC2_HUMAN) Sequence A:  TNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDA DATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQ FGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKED TMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVE KFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFN LKLMDNGEPELDIISNPRDIQMAETKPERRSFRAYAAVLY IDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRA EQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDS RVMLRQVQNRAITLRREADVKKRIKEAKQRALKEPKELNF VFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACG GVVGVVDVPYLVLEPRHNKQDFADAKEYRHLLRAMGEHLA QYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRYKRR RAMEIPTTIQCDLCLKWRTLPDTWVCSMNPDPEQDRCEAS EQKQKVPLGTF Description (1)  MORC family CW-type zinc finger protein 2 Functional site 1) chain A residue 499 type sequence C description binding site for residue ZN A 701 source : AC4 2) chain A residue 502 type sequence C description binding site for residue ZN A 701 source : AC4 3) chain A residue 525 type sequence C description binding site for residue ZN A 701 source : AC4 4) chain A residue 536 type sequence C description binding site for residue ZN A 701 source : AC4 5) chain A residue 35 type sequence E description binding site for residue ANP A 702 source : AC5 6) chain A residue 39 type sequence N description binding site for residue ANP A 702 source : AC5 7) chain A residue 43 type sequence A description binding site for residue ANP A 702 source : AC5 8) chain A residue 68 type sequence D description binding site for residue ANP A 702 source : AC5 9) chain A residue 73 type sequence M description binding site for residue ANP A 702 source : AC5 10) chain A residue 81 type sequence V description binding site for residue ANP A 702 source : AC5 11) chain A residue 87 type sequence S description binding site for residue ANP A 702 source : AC5 12) chain A residue 89 type sequence K description binding site for residue ANP A 702 source : AC5 13) chain A residue 98 type sequence G description binding site for residue ANP A 702 source : AC5 14) chain A residue 99 type sequence Q description binding site for residue ANP A 702 source : AC5 15) chain A residue 100 type sequence Y description binding site for residue ANP A 702 source : AC5 16) chain A residue 101 type sequence G description binding site for residue ANP A 702 source : AC5 17) chain A residue 102 type sequence N description binding site for residue ANP A 702 source : AC5 18) chain A residue 103 type sequence G description binding site for residue ANP A 702 source : AC5 19) chain A residue 104 type sequence L description binding site for residue ANP A 702 source : AC5 20) chain A residue 105 type sequence K description binding site for residue ANP A 702 source : AC5 21) chain A residue 197 type sequence T description binding site for residue ANP A 702 source : AC5 22) chain A residue 427 type sequence K description binding site for residue ANP A 702 source : AC5 23) chain A residue 39 type sequence N description binding site for residue MG A 703 source : AC6 24) chain A residue 490-544 type ZN_FING sequence AMEIPTTIQCDLCLKWRTLPDTWVCSMNPDPEQDRCEASE QKQK description CW-type => ECO:0000255|PROSITE-ProRule:PRU00454, ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 39 type BINDING sequence N description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 87 type BINDING sequence S description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 99 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 427 type BINDING sequence K description BINDING => ECO:0000269|PubMed:29440755 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 499 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 502 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 525 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 536 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00454 source Swiss-Prot : SWS_FT_FI3

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