eF-site ID 5oct-F PDB Code 5oct Chain F click to enlarge Title Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. Classification HYDROLASE Compound GTPase KRas Source (RASK_HUMAN) Sequence F:  YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTI EDSYRKQVVIDGETXLLDILDTAGRDQYMRTGEGFLCVFA INNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSR TVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREI RKHKE Description Functional site 1) chain F residue 12 type sequence G description binding site for residue GNP F 201 source : AE1 2) chain F residue 13 type sequence G description binding site for residue GNP F 201 source : AE1 3) chain F residue 14 type sequence V description binding site for residue GNP F 201 source : AE1 4) chain F residue 15 type sequence G description binding site for residue GNP F 201 source : AE1 5) chain F residue 16 type sequence K description binding site for residue GNP F 201 source : AE1 6) chain F residue 17 type sequence S description binding site for residue GNP F 201 source : AE1 7) chain F residue 18 type sequence A description binding site for residue GNP F 201 source : AE1 8) chain F residue 28 type sequence F description binding site for residue GNP F 201 source : AE1 9) chain F residue 29 type sequence V description binding site for residue GNP F 201 source : AE1 10) chain F residue 30 type sequence D description binding site for residue GNP F 201 source : AE1 11) chain F residue 32 type sequence Y description binding site for residue GNP F 201 source : AE1 12) chain F residue 34 type sequence P description binding site for residue GNP F 201 source : AE1 13) chain F residue 35 type sequence T description binding site for residue GNP F 201 source : AE1 14) chain F residue 60 type sequence G description binding site for residue GNP F 201 source : AE1 15) chain F residue 116 type sequence N description binding site for residue GNP F 201 source : AE1 16) chain F residue 117 type sequence K description binding site for residue GNP F 201 source : AE1 17) chain F residue 119 type sequence D description binding site for residue GNP F 201 source : AE1 18) chain F residue 120 type sequence L description binding site for residue GNP F 201 source : AE1 19) chain F residue 145 type sequence S description binding site for residue GNP F 201 source : AE1 20) chain F residue 146 type sequence A description binding site for residue GNP F 201 source : AE1 21) chain F residue 147 type sequence K description binding site for residue GNP F 201 source : AE1 22) chain F residue 7 type sequence V description binding site for residue 9R5 F 202 source : AE2 23) chain F residue 39 type sequence S description binding site for residue 9R5 F 202 source : AE2 24) chain F residue 54 type sequence D description binding site for residue 9R5 F 202 source : AE2 25) chain F residue 74 type sequence T description binding site for residue 9R5 F 202 source : AE2 26) chain F residue 75 type sequence G description binding site for residue 9R5 F 202 source : AE2 27) chain F residue 68 type sequence R description binding site for residue 9R5 F 203 source : AE3 28) chain F residue 88 type sequence K description binding site for residue 9R5 F 203 source : AE3 29) chain F residue 92 type sequence D description binding site for residue 9R5 F 203 source : AE3 30) chain F residue 95 type sequence H description binding site for residue 9R5 F 203 source : AE3 31) chain F residue 96 type sequence Y description binding site for residue 9R5 F 203 source : AE3 32) chain F residue 99 type sequence Q description binding site for residue 9R5 F 203 source : AE3 33) chain F residue 124 type sequence T description binding site for residue DMS F 204 source : AE4 34) chain F residue 126 type sequence D description binding site for residue DMS F 204 source : AE4 35) chain F residue 129 type sequence Q description binding site for residue DMS F 204 source : AE4 36) chain F residue 17 type sequence S description binding site for residue MG F 205 source : AE5 37) chain F residue 35 type sequence T description binding site for residue MG F 205 source : AE5 38) chain F residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 39) chain F residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 40) chain F residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 41) chain F residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 42) chain F residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI2 43) chain F residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI3 44) chain F residue 104 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:22711838 source Swiss-Prot : SWS_FT_FI4 45) chain F residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 source Swiss-Prot : SWS_FT_FI5

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