eF-site ID 5oct-E PDB Code 5oct Chain E click to enlarge Title Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. Classification HYDROLASE Compound GTPase KRas Source (RASK_HUMAN) Sequence E:  YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTI EDSYRKQVVIDGETXLLDILDTAGRDQYMRTGEGFLCVFA INNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSR TVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREI RKHKE Description Functional site 1) chain E residue 11 type sequence A description binding site for residue GNP E 201 source : AD6 2) chain E residue 12 type sequence G description binding site for residue GNP E 201 source : AD6 3) chain E residue 13 type sequence G description binding site for residue GNP E 201 source : AD6 4) chain E residue 14 type sequence V description binding site for residue GNP E 201 source : AD6 5) chain E residue 15 type sequence G description binding site for residue GNP E 201 source : AD6 6) chain E residue 16 type sequence K description binding site for residue GNP E 201 source : AD6 7) chain E residue 17 type sequence S description binding site for residue GNP E 201 source : AD6 8) chain E residue 18 type sequence A description binding site for residue GNP E 201 source : AD6 9) chain E residue 28 type sequence F description binding site for residue GNP E 201 source : AD6 10) chain E residue 29 type sequence V description binding site for residue GNP E 201 source : AD6 11) chain E residue 30 type sequence D description binding site for residue GNP E 201 source : AD6 12) chain E residue 31 type sequence E description binding site for residue GNP E 201 source : AD6 13) chain E residue 32 type sequence Y description binding site for residue GNP E 201 source : AD6 14) chain E residue 34 type sequence P description binding site for residue GNP E 201 source : AD6 15) chain E residue 35 type sequence T description binding site for residue GNP E 201 source : AD6 16) chain E residue 60 type sequence G description binding site for residue GNP E 201 source : AD6 17) chain E residue 116 type sequence N description binding site for residue GNP E 201 source : AD6 18) chain E residue 117 type sequence K description binding site for residue GNP E 201 source : AD6 19) chain E residue 119 type sequence D description binding site for residue GNP E 201 source : AD6 20) chain E residue 120 type sequence L description binding site for residue GNP E 201 source : AD6 21) chain E residue 145 type sequence S description binding site for residue GNP E 201 source : AD6 22) chain E residue 146 type sequence A description binding site for residue GNP E 201 source : AD6 23) chain E residue 5 type sequence K description binding site for residue 9R5 E 202 source : AD7 24) chain E residue 7 type sequence V description binding site for residue 9R5 E 202 source : AD7 25) chain E residue 39 type sequence S description binding site for residue 9R5 E 202 source : AD7 26) chain E residue 54 type sequence D description binding site for residue 9R5 E 202 source : AD7 27) chain E residue 56 type sequence L description binding site for residue 9R5 E 202 source : AD7 28) chain E residue 71 type sequence Y description binding site for residue 9R5 E 202 source : AD7 29) chain E residue 74 type sequence T description binding site for residue 9R5 E 202 source : AD7 30) chain E residue 75 type sequence G description binding site for residue 9R5 E 202 source : AD7 31) chain E residue 68 type sequence R description binding site for residue 9R5 E 203 source : AD8 32) chain E residue 88 type sequence K description binding site for residue 9R5 E 203 source : AD8 33) chain E residue 92 type sequence D description binding site for residue 9R5 E 203 source : AD8 34) chain E residue 96 type sequence Y description binding site for residue 9R5 E 203 source : AD8 35) chain E residue 99 type sequence Q description binding site for residue 9R5 E 203 source : AD8 36) chain E residue 17 type sequence S description binding site for residue MG E 204 source : AD9 37) chain E residue 35 type sequence T description binding site for residue MG E 204 source : AD9 38) chain E residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 39) chain E residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 40) chain E residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 41) chain E residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 42) chain E residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI2 43) chain E residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI3 44) chain E residue 104 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:22711838 source Swiss-Prot : SWS_FT_FI4 45) chain E residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 source Swiss-Prot : SWS_FT_FI5

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