eF-site ID 5oct-B PDB Code 5oct Chain B click to enlarge Title Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. Classification HYDROLASE Compound GTPase KRas Source (RASK_HUMAN) Sequence B:  YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTI EDSYRKQVVIDGETXLLDILDTAGHSAMRDQYMRTGEGFL CVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCD LPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTL VREIRKHKE Description Functional site 1) chain B residue 22 type sequence Q description binding site for residue PEG A 203 source : AC3 2) chain B residue 28 type sequence F description binding site for residue PEG A 203 source : AC3 3) chain B residue 147 type sequence K description binding site for residue PEG A 203 source : AC3 4) chain B residue 12 type sequence G description binding site for residue GNP B 201 source : AC5 5) chain B residue 13 type sequence G description binding site for residue GNP B 201 source : AC5 6) chain B residue 14 type sequence V description binding site for residue GNP B 201 source : AC5 7) chain B residue 15 type sequence G description binding site for residue GNP B 201 source : AC5 8) chain B residue 16 type sequence K description binding site for residue GNP B 201 source : AC5 9) chain B residue 17 type sequence S description binding site for residue GNP B 201 source : AC5 10) chain B residue 18 type sequence A description binding site for residue GNP B 201 source : AC5 11) chain B residue 28 type sequence F description binding site for residue GNP B 201 source : AC5 12) chain B residue 29 type sequence V description binding site for residue GNP B 201 source : AC5 13) chain B residue 30 type sequence D description binding site for residue GNP B 201 source : AC5 14) chain B residue 31 type sequence E description binding site for residue GNP B 201 source : AC5 15) chain B residue 32 type sequence Y description binding site for residue GNP B 201 source : AC5 16) chain B residue 34 type sequence P description binding site for residue GNP B 201 source : AC5 17) chain B residue 35 type sequence T description binding site for residue GNP B 201 source : AC5 18) chain B residue 60 type sequence G description binding site for residue GNP B 201 source : AC5 19) chain B residue 116 type sequence N description binding site for residue GNP B 201 source : AC5 20) chain B residue 117 type sequence K description binding site for residue GNP B 201 source : AC5 21) chain B residue 119 type sequence D description binding site for residue GNP B 201 source : AC5 22) chain B residue 120 type sequence L description binding site for residue GNP B 201 source : AC5 23) chain B residue 145 type sequence S description binding site for residue GNP B 201 source : AC5 24) chain B residue 146 type sequence A description binding site for residue GNP B 201 source : AC5 25) chain B residue 5 type sequence K description binding site for residue 9R5 B 202 source : AC6 26) chain B residue 39 type sequence S description binding site for residue 9R5 B 202 source : AC6 27) chain B residue 54 type sequence D description binding site for residue 9R5 B 202 source : AC6 28) chain B residue 56 type sequence L description binding site for residue 9R5 B 202 source : AC6 29) chain B residue 74 type sequence T description binding site for residue 9R5 B 202 source : AC6 30) chain B residue 75 type sequence G description binding site for residue 9R5 B 202 source : AC6 31) chain B residue 17 type sequence S description binding site for residue MG B 203 source : AC7 32) chain B residue 35 type sequence T description binding site for residue MG B 203 source : AC7 33) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 104 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:22711838 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 source Swiss-Prot : SWS_FT_FI5

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