|
|
eF-site ID
|
5oca-B |
|
PDB Code
|
5oca |
|
Chain
|
B |
|
click to enlarge
|
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Title
|
PCSK9:Fab Complex with Dextran Sulfate |
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Classification
|
HYDROLASE |
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Compound
|
Proprotein convertase subtilisin/kexin type 9 |
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Source
|
(5OCA) |
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Sequence
|
B: |
SIPWNLERITPPRYRADLVEVYLLDTSIQSDHREIEGRVM
VTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGV
AKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVG
PLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDD
ACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDL
FAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLS
AEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLV
AALPPSTHQLFCRTVWSAHSGPTRMATAIARCAPDEELLS
CSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIAR
CCLLPQAACSVHTAPPAEASMGTRVHCHQQGHVLTGCSSH
WEVEDLGTPNQCVGHREASIHASCCHAPGLECKVKEHGIP
APQGQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVV
RSRAVTAVAICCRSR
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|
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Description
|
(1) |
Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
186 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
226 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
386 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
218 |
| type |
SITE |
| sequence |
R
|
| description |
Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
533 |
| type |
CARBOHYD |
| sequence |
A
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|