eF-site ID 5oca-ABHL PDB Code 5oca Chain A, B, H, L click to enlarge Title PCSK9:Fab Complex with Dextran Sulfate Classification HYDROLASE Compound Proprotein convertase subtilisin/kexin type 9 Source (5OCA) Sequence A:  TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQA QAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHV DYIEEDSSVFAQ B:  SIPWNLERITPPRYRADLVEVYLLDTSIQSDHREIEGRVM VTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGV AKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVG PLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDD ACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDL FAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLS AEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLV AALPPSTHQLFCRTVWSAHSGPTRMATAIARCAPDEELLS CSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIAR CCLLPQAACSVHTAPPAEASMGTRVHCHQQGHVLTGCSSH WEVEDLGTPNQCVGHREASIHASCCHAPGLECKVKEHGIP APQGQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVV RSRAVTAVAICCRSR H:  EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQA PGKGLEWVSSISSSSSYISYADSVKGRFTISRDNAKNSLY LQMNSLRAEDTAVYFCARDYDFWSAYYDAFDVWGQGTMVT VSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWN SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI CNVNHKPSNTKVDKKVEPK L:  ESVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQ LPGTAPKLLISGNSNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKAAPSV TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQV THEGSTVEKTVAPT Description (1)  Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain Functional site 1) chain L residue 196-202 type prosite sequence YSCQVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH source prosite : PS00290 2) chain H residue 204-210 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH source prosite : PS00290 3) chain B residue 186 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 226 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 386 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 218 type SITE sequence R description Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 533 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links