Title
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PCSK9:Fab Complex with Dextran Sulfate |
Classification
|
HYDROLASE |
Compound
|
Proprotein convertase subtilisin/kexin type 9 |
Source
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(5OCA) |
|
Sequence
|
A: |
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQA
QAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHV
DYIEEDSSVFAQ
|
B: |
SIPWNLERITPPRYRADLVEVYLLDTSIQSDHREIEGRVM
VTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGV
AKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVG
PLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDD
ACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDL
FAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLS
AEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLV
AALPPSTHQLFCRTVWSAHSGPTRMATAIARCAPDEELLS
CSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIAR
CCLLPQAACSVHTAPPAEASMGTRVHCHQQGHVLTGCSSH
WEVEDLGTPNQCVGHREASIHASCCHAPGLECKVKEHGIP
APQGQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVV
RSRAVTAVAICCRSR
|
H: |
EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQA
PGKGLEWVSSISSSSSYISYADSVKGRFTISRDNAKNSLY
LQMNSLRAEDTAVYFCARDYDFWSAYYDAFDVWGQGTMVT
VSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEPK
|
L: |
ESVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQ
LPGTAPKLLISGNSNRPSGVPDRFSGSKSGTSASLAITGL
QAEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKAAPSV
TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV
KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQV
THEGSTVEKTVAPT
|
|
Description
|
(1) |
Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain
|