eF-site ID 5oca-ABHL
PDB Code 5oca
Chain A, B, H, L

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Title PCSK9:Fab Complex with Dextran Sulfate
Classification HYDROLASE
Compound Proprotein convertase subtilisin/kexin type 9
Source (5OCA)
Sequence A:  TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQA
QAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHV
DYIEEDSSVFAQ
B:  SIPWNLERITPPRYRADLVEVYLLDTSIQSDHREIEGRVM
VTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGV
AKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVG
PLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDD
ACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDL
FAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLS
AEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLV
AALPPSTHQLFCRTVWSAHSGPTRMATAIARCAPDEELLS
CSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIAR
CCLLPQAACSVHTAPPAEASMGTRVHCHQQGHVLTGCSSH
WEVEDLGTPNQCVGHREASIHASCCHAPGLECKVKEHGIP
APQGQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVV
RSRAVTAVAICCRSR
H:  EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQA
PGKGLEWVSSISSSSSYISYADSVKGRFTISRDNAKNSLY
LQMNSLRAEDTAVYFCARDYDFWSAYYDAFDVWGQGTMVT
VSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEPK
L:  ESVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQ
LPGTAPKLLISGNSNRPSGVPDRFSGSKSGTSASLAITGL
QAEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKAAPSV
TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV
KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQV
THEGSTVEKTVAPT
Description (1)  Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain


Functional site

1) chain L
residue 196-202
type prosite
sequence YSCQVTH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
source prosite : PS00290

2) chain H
residue 204-210
type prosite
sequence YICNVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
source prosite : PS00290

3) chain B
residue 186
type ACT_SITE
sequence D
description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
source Swiss-Prot : SWS_FT_FI1

4) chain B
residue 226
type ACT_SITE
sequence H
description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
source Swiss-Prot : SWS_FT_FI1

5) chain B
residue 386
type ACT_SITE
sequence S
description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240
source Swiss-Prot : SWS_FT_FI1

6) chain B
residue 218
type SITE
sequence R
description Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035
source Swiss-Prot : SWS_FT_FI2

7) chain B
residue 533
type CARBOHYD
sequence A
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035
source Swiss-Prot : SWS_FT_FI4


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