eF-site ID 5o76-A PDB Code 5o76 Chain A click to enlarge Title Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant Classification LIGASE Compound E3 ubiquitin-protein ligase CBL Source Homo sapiens (Human) (5O76) Sequence A:  TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLP DTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQT ISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIF PSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQAL HEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQ PWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPG SYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALI DGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQFE LXCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQ ESEGQGCPFCRCEIKGTEPIVVDPF Description Functional site 1) chain A residue 381 type sequence C description binding site for residue ZN A 501 source : AC1 2) chain A residue 384 type sequence C description binding site for residue ZN A 501 source : AC1 3) chain A residue 401 type sequence C description binding site for residue ZN A 501 source : AC1 4) chain A residue 404 type sequence C description binding site for residue ZN A 501 source : AC1 5) chain A residue 396 type sequence C description binding site for residue ZN A 502 source : AC2 6) chain A residue 398 type sequence H description binding site for residue ZN A 502 source : AC2 7) chain A residue 416 type sequence C description binding site for residue ZN A 502 source : AC2 8) chain A residue 419 type sequence C description binding site for residue ZN A 502 source : AC2 9) chain A residue 229 type sequence D description binding site for residue CA A 503 source : AC3 10) chain A residue 231 type sequence T description binding site for residue CA A 503 source : AC3 11) chain A residue 233 type sequence N description binding site for residue CA A 503 source : AC3 12) chain A residue 235 type sequence Y description binding site for residue CA A 503 source : AC3 13) chain A residue 240 type sequence E description binding site for residue CA A 503 source : AC3 14) chain A residue 396-405 type prosite sequence CGHLMCTSCL description ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL source prosite : PS00518 15) chain A residue 233 type MOD_RES sequence N description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 235 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 240 type MOD_RES sequence E description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 371 type MOD_RES sequence X description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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