eF-site ID 5o76-C PDB Code 5o76 Chain C click to enlarge Title Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant Classification LIGASE Compound E3 ubiquitin-protein ligase CBL Source Homo sapiens (Human) (5O76) Sequence C:  PGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDL LPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTK QTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKG IFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQ ALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRL FQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQA LIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQ FELXCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTS WQESEGQGCPFCRCEIKGTEPIVVDPF Description Functional site 1) chain C residue 381 type sequence C description binding site for residue ZN C 501 source : AC4 2) chain C residue 384 type sequence C description binding site for residue ZN C 501 source : AC4 3) chain C residue 401 type sequence C description binding site for residue ZN C 501 source : AC4 4) chain C residue 404 type sequence C description binding site for residue ZN C 501 source : AC4 5) chain C residue 396 type sequence C description binding site for residue ZN C 502 source : AC5 6) chain C residue 398 type sequence H description binding site for residue ZN C 502 source : AC5 7) chain C residue 416 type sequence C description binding site for residue ZN C 502 source : AC5 8) chain C residue 229 type sequence D description binding site for residue CA C 503 source : AC6 9) chain C residue 231 type sequence T description binding site for residue CA C 503 source : AC6 10) chain C residue 233 type sequence N description binding site for residue CA C 503 source : AC6 11) chain C residue 235 type sequence Y description binding site for residue CA C 503 source : AC6 12) chain C residue 240 type sequence E description binding site for residue CA C 503 source : AC6 13) chain C residue 274 type sequence Y description binding site for Di-peptide GLY D 6 and PTR D 7 source : AC7 14) chain C residue 294 type sequence R description binding site for Di-peptide GLY D 6 and PTR D 7 source : AC7 15) chain C residue 296 type sequence S description binding site for Di-peptide GLY D 6 and PTR D 7 source : AC7 16) chain C residue 297 type sequence C description binding site for Di-peptide GLY D 6 and PTR D 7 source : AC7 17) chain C residue 298 type sequence T description binding site for Di-peptide GLY D 6 and PTR D 7 source : AC7 18) chain C residue 316 type sequence Q description binding site for Di-peptide GLY D 6 and PTR D 7 source : AC7 19) chain C residue 274 type sequence Y description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 20) chain C residue 294 type sequence R description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 21) chain C residue 296 type sequence S description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 22) chain C residue 297 type sequence C description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 23) chain C residue 298 type sequence T description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 24) chain C residue 315 type sequence L description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 25) chain C residue 316 type sequence Q description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 26) chain C residue 317 type sequence T description binding site for Di-peptide PTR D 7 and THR D 8 source : AC8 27) chain C residue 240 type MOD_RES sequence E description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 28) chain C residue 229 type MOD_RES sequence D description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 29) chain C residue 231 type MOD_RES sequence T description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 30) chain C residue 233 type MOD_RES sequence N description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 31) chain C residue 235 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 32) chain C residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain C residue 371 type MOD_RES sequence X description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4

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