eF-site ID 5o0y-A PDB Code 5o0y Chain A click to enlarge Title TLK2 kinase domain from human Classification TRANSFERASE Compound Serine/threonine-protein kinase tousled-like 2 Source (TLK2_HUMAN) Sequence A:  PTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQL NKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL DTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIV NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFG LSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEP PKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT ILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQL ACDPYLLP Description Functional site 1) chain A residue 468 type sequence L description binding site for residue AGS A 801 source : AC1 2) chain A residue 470 type sequence R description binding site for residue AGS A 801 source : AC1 3) chain A residue 471 type sequence G description binding site for residue AGS A 801 source : AC1 4) chain A residue 472 type sequence G description binding site for residue AGS A 801 source : AC1 5) chain A residue 474 type sequence S description binding site for residue AGS A 801 source : AC1 6) chain A residue 476 type sequence V description binding site for residue AGS A 801 source : AC1 7) chain A residue 485 type sequence Q description binding site for residue AGS A 801 source : AC1 8) chain A residue 489 type sequence A description binding site for residue AGS A 801 source : AC1 9) chain A residue 491 type sequence K description binding site for residue AGS A 801 source : AC1 10) chain A residue 545 type sequence E description binding site for residue AGS A 801 source : AC1 11) chain A residue 547 type sequence C description binding site for residue AGS A 801 source : AC1 12) chain A residue 468-491 type prosite sequence LGRGGFSEVYKAFDLTEQRYVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFSEVYkAfdlteqry..........VAVK source prosite : PS00107 13) chain A residue 588-600 type prosite sequence IIHYDLKPGNILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHyDLKpgNILL source prosite : PS00108 14) chain A residue 592 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 15) chain A residue 468 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 491 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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