eF-site ID 5nvn-C PDB Code 5nvn Chain C click to enlarge Title Crystal structure of the human 4EHP-4E-BP1 complex Classification TRANSLATION Compound Eukaryotic translation initiation factor 4E type 2 Source Homo sapiens (Human) (4EBP1_HUMAN) Sequence C:  GPHMLEAEHPLQYNYTFWYSRRNIKQIGTFASVEQFWRFY SHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIR LRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQED IISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHT DSIKMP Description Functional site 1) chain C residue 198 type sequence D description binding site for residue FMT A 301 source : AC1 2) chain C residue 199 type sequence T description binding site for residue FMT C 301 source : AC2 3) chain C residue 202 type sequence R description binding site for residue FMT C 301 source : AC2 4) chain C residue 160 type sequence F description binding site for residue FMT C 302 source : AC3 5) chain C residue 161 type sequence M description binding site for residue FMT C 302 source : AC3 6) chain C residue 195 type sequence R description binding site for residue FMT C 302 source : AC3 7) chain C residue 199 type sequence T description binding site for residue FMT C 302 source : AC3 8) chain C residue 139 type sequence L description binding site for residue FMT C 303 source : AC4 9) chain C residue 140 type sequence R description binding site for residue FMT C 303 source : AC4 10) chain C residue 143 type sequence L description binding site for residue FMT C 303 source : AC4 11) chain C residue 177 type sequence E description binding site for residue FMT C 304 source : AC5 12) chain C residue 146 type sequence R description binding site for residue FMT C 305 source : AC6 13) chain C residue 150 type sequence N description binding site for residue FMT C 305 source : AC6 14) chain C residue 205 type sequence N description binding site for residue FMT C 305 source : AC6 15) chain C residue 222 type sequence K description binding site for residue FMT C 306 source : AC7 16) chain C residue 222 type MOD_RES sequence K description Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 110 type MOD_RES sequence H description Phosphotyrosine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI2 18) chain C residue 124 type MOD_RES sequence W description Phosphotyrosine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI2 19) chain C residue 174 type MOD_RES sequence R description Phosphotyrosine => ECO:0007744|PubMed:18669648 source Swiss-Prot : SWS_FT_FI2 20) chain C residue 222 type MOD_RES sequence K description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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