|
|
eF-site ID
|
5nvn-B |
|
PDB Code
|
5nvn |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
Crystal structure of the human 4EHP-4E-BP1 complex |
|
Classification
|
TRANSLATION |
|
Compound
|
Eukaryotic translation initiation factor 4E type 2 |
|
Source
|
Homo sapiens (Human) (4EBP1_HUMAN) |
|
|
Sequence
|
B: |
TRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTS
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
72 |
| type |
|
| sequence |
P
|
| description |
binding site for residue FMT A 301
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
74 |
| type |
|
| sequence |
D
|
| description |
binding site for residue FMT A 301
|
| source |
: AC1
|
|
|
3)
|
chain |
B |
| residue |
73 |
| type |
|
| sequence |
R
|
| description |
binding site for residue FMT C 301
|
| source |
: AC2
|
|
|
4)
|
chain |
B |
| residue |
73 |
| type |
|
| sequence |
R
|
| description |
binding site for residue FMT C 302
|
| source |
: AC3
|
|
|
5)
|
chain |
B |
| residue |
57 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
6)
|
chain |
B |
| residue |
50 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
B |
| residue |
54 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
B |
| residue |
65 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
B |
| residue |
70 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by MTOR => ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
10)
|
chain |
B |
| residue |
77 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
11)
|
chain |
B |
| residue |
83 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:18669648
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|